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    CLC-F chloride channel F [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842011, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CLC-F
    Official Full Name
    chloride channel F
    Primary source
    TAIR:AT1G55620
    Locus tag
    AT1G55620
    See related
    Araport:AT1G55620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCLC-F; chloride channel F; CHLORIDE CHANNEL F; CLCF; F20N2.5
    Summary
    Encodes a chloride channel protein that has been localized to the chloroplast and golgi apparatus. Complements yeast gef1 mutant and therefor may function to acidify the golgi lumen.
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    Genomic context

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    See CLC-F in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (20787074..20791208, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene BRI1 like Neighboring gene tRNA-Ser Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Localization of a putative ClC chloride channel in spinach chloroplasts. Teardo E, et al. FEBS Lett, 2005 Sep 12. PMID 16115625
    2. Two members of the Arabidopsis CLC (chloride channel) family, AtCLCe and AtCLCf, are associated with thylakoid and Golgi membranes, respectively. Marmagne A, et al. J Exp Bot, 2007. PMID 17872921
    3. Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Parsons HT, et al. Plant Physiol, 2012 May. PMID 22430844, Free PMC Article
    4. Multi-omics network-based functional annotation of unknown Arabidopsis genes. Depuydt T, et al. Plant J, 2021 Nov. PMID 34562334
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_104438.4
    NM_179482.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables voltage-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chloride channel F
    NP_564698.1
    • chloride channel F (CLC-F); FUNCTIONS IN: ion channel activity, voltage-gated chloride channel activity; INVOLVED IN: chloride transport, transmembrane transport; LOCATED IN: Golgi apparatus, chloroplast, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Chloride channel, core (InterPro:IPR014743), Chloride channel, voltage gated (InterPro:IPR001807), Cystathionine beta-synthase, core (InterPro:IPR000644); BEST Arabidopsis thaliana protein match is: chloride channel E (TAIR:AT4G35440.1); Has 8626 Blast hits to 8538 proteins in 2008 species: Archae - 276; Bacteria - 6042; Metazoa - 796; Fungi - 384; Plants - 229; Viruses - 0; Other Eukaryotes - 899 (source: NCBI BLink).
    NP_849813.1
    • chloride channel F (CLC-F); FUNCTIONS IN: ion channel activity, voltage-gated chloride channel activity; INVOLVED IN: chloride transport, transmembrane transport; LOCATED IN: Golgi apparatus, chloroplast, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Chloride channel, core (InterPro:IPR014743), Chloride channel, voltage gated (InterPro:IPR001807), Cystathionine beta-synthase, core (InterPro:IPR000644); BEST Arabidopsis thaliana protein match is: chloride channel E (TAIR:AT4G35440.2); Has 8610 Blast hits to 8392 proteins in 1951 species: Archae - 280; Bacteria - 6051; Metazoa - 795; Fungi - 382; Plants - 225; Viruses - 0; Other Eukaryotes - 877 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20787074..20791208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104438.4 → NP_564698.1  chloride channel F [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564698.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RXR2, Q9ARM3, Q9LG04
      UniProtKB/TrEMBL
      A0A178W259, A0A5S9WM51, A0A7G2E1E1
      Conserved Domains (3) summary
      PLN02274
      Location:567 → 673
      PLN02274; inosine-5'-monophosphate dehydrogenase
      cd00400
      Location:139 → 544
      Voltage_gated_ClC; CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This ...
      cd04592
      Location:621 → 754
      CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

    2. NM_179482.3 → NP_849813.1  chloride channel F [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849813.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RXR2
      Conserved Domains (3) summary
      PLN02274
      Location:371 → 477
      PLN02274; inosine-5'-monophosphate dehydrogenase
      cd00400
      Location:3 → 348
      Voltage_gated_ClC; CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This ...
      cd04592
      Location:425 → 558
      CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8RXR2.2

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