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    UBP6 ubiquitin-specific protease 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841596, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UBP6
    Official Full Name
    ubiquitin-specific protease 6
    Primary source
    TAIR:AT1G51710
    Locus tag
    AT1G51710
    See related
    Araport:AT1G51710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATUBP6; F19C24.8; F19C24_8; ubiquitin-specific protease 6; UBIQUITIN-SPECIFIC PROTEASE 6
    Summary
    Ubiquitin-specific protease 6 (UBP6). Deubiquinating enzyme. Interacts with calmodulin.
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    Genomic context

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    See UBP6 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    17
    Sequence:
    Chromosome: 1; NC_003070.9 (19175609..19180195, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DOF zinc finger protein 1 Neighboring gene Amino acid dehydrogenase family protein Neighboring gene Ubiquitin-conjugating enzyme family protein Neighboring gene syntaxin of plants 81

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis ubiquitin-specific protease 6 (AtUBP6) interacts with calmodulin. Moon BC, et al. FEBS Lett, 2005 Jul 18. PMID 15987637
    2. The Arabidopsis metacaspase9 degradome. Tsiatsiani L, et al. Plant Cell, 2013 Aug. PMID 23964026, Free PMC Article
    3. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article
    4. Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics. Kim TW, et al. Plant Cell, 2023 Mar 15. PMID 36660928, Free PMC Article
    5. Arabidopsis plasmodesmal proteome. Fernandez-Calvino L, et al. PLoS One, 2011 Apr 20. PMID 21533090, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtUBP6 interacts with calmodulin
      Title: Arabidopsis ubiquitin-specific protease 6 (AtUBP6) interacts with calmodulin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084229.1
    NM_104049.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein deubiquitination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    ubiquitin-specific protease 6
    NP_001077698.1
    • ubiquitin-specific protease 6 (UBP6); CONTAINS InterPro DOMAIN/s: Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site (InterPro:IPR018200), Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 (InterPro:IPR001394); BEST Arabidopsis thaliana protein match is: ubiquitin-specific protease 7 (TAIR:AT3G21280.1); Has 4803 Blast hits to 4486 proteins in 237 species: Archae - 0; Bacteria - 0; Metazoa - 2534; Fungi - 849; Plants - 654; Viruses - 2; Other Eukaryotes - 764 (source: NCBI BLink).
    NP_564596.1
    • ubiquitin-specific protease 6 (UBP6); CONTAINS InterPro DOMAIN/s: Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site (InterPro:IPR018200), Ubiquitin conserved site (InterPro:IPR019954), Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 (InterPro:IPR001394), Ubiquitin (InterPro:IPR000626), Ubiquitin supergroup (InterPro:IPR019955); BEST Arabidopsis thaliana protein match is: ubiquitin-specific protease 7 (TAIR:AT3G21280.1); Has 4793 Blast hits to 4476 proteins in 238 species: Archae - 0; Bacteria - 0; Metazoa - 2508; Fungi - 875; Plants - 657; Viruses - 2; Other Eukaryotes - 751 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19175609..19180195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104049.4 → NP_564596.1  ubiquitin-specific protease 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564596.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56ZE7, Q949Y0, Q9C8H9, Q9FPT4
      UniProtKB/TrEMBL
      A0A178WJ56, A0A5S9WL23, A0A7G2E3S0
      Conserved Domains (2) summary
      cd02657
      Location:105 → 476
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      cd16104
      Location:1 → 75
      Ubl_USP14_like; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 14 (USP14) and similar proteins

    2. NM_001084229.1 → NP_001077698.1  ubiquitin-specific protease 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077698.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2E3S0, B3H5V4
      Conserved Domains (2) summary
      cd02657
      Location:66 → 437
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      pfam00443
      Location:65 → 436
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q949Y0.1

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