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    GCR1 G-protein-coupled receptor 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841247, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GCR1
    Official Full Name
    G-protein-coupled receptor 1
    Primary source
    TAIR:AT1G48270
    Locus tag
    AT1G48270
    See related
    Araport:AT1G48270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F11A17.17; F11A17_17; G-protein-coupled receptor 1
    Summary
    encodes a protein similar to G-coupled receptor with 7 transmembrane regions. Overexpression studies suggest this gene is involved in dormancy and flowering. Reduction of expression results in decreased sensitivity to cytokinin.
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    Genomic context

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    See GCR1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (17827953..17830420, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GCR1 can act independently of heterotrimeric G-protein in response to brassinosteroids and gibberellins in Arabidopsis seed germination. Chen JG, et al. Plant Physiol, 2004 Jun. PMID 15181210, Free PMC Article
    2. The G-protein-coupled receptor GCR1 regulates DNA synthesis through activation of phosphatidylinositol-specific phospholipase C. Apone F, et al. Plant Physiol, 2003 Oct. PMID 12972659, Free PMC Article
    3. GCR1, the putative Arabidopsis G protein-coupled receptor gene is cell cycle-regulated, and its overexpression abolishes seed dormancy and shortens time to flowering. Colucci G, et al. Proc Natl Acad Sci U S A, 2002 Apr 2. PMID 11930019, Free PMC Article
    4. A higher plant seven-transmembrane receptor that influences sensitivity to cytokinins. Plakidou-Dymock S, et al. Curr Biol, 1998 Mar 12. PMID 9512416
    5. G-protein α-subunit (GPA1) regulates stress, nitrate and phosphate response, flavonoid biosynthesis, fruit/seed development and substantially shares GCR1 regulation in A. thaliana. Chakraborty N, et al. Plant Mol Biol, 2015 Dec. PMID 26346778

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. provide compelling genetic evidence to revisit the role of GCR1 in G-protein signalling
      Title: G-protein α-subunit (GPA1) regulates stress, nitrate and phosphate response, flavonoid biosynthesis, fruit/seed development and substantially shares GCR1 regulation in A. thaliana.
    2. GCR1 and GPA1 are involved in N-acyl-homoserine lactones -mediated elongation of Arabidopsis roots.
      Title: The GCR1 and GPA1 participate in promotion of Arabidopsis primary root elongation induced by N-acyl-homoserine lactones, the bacterial quorum-sensing signals.
    3. GCR1 plays a positive role in gibberellin and brassinosteroid regulated seed germination. Unlike a typical 7TM receptor, it acts independently of the heterotrimeric G-protein.
      Title: GCR1 can act independently of heterotrimeric G-protein in response to brassinosteroids and gibberellins in Arabidopsis seed germination.
    4. GCR1 may act as a negative regulator of G protein alpha subunit GPA1-mediated abscisic acid responses in guard cells [GCR1]
      Title: The Arabidopsis putative G protein-coupled receptor GCR1 interacts with the G protein alpha subunit GPA1 and regulates abscisic acid signaling.
    5. G-protein-coupled receptor 1, G-protein Galpha-subunit 1, and prephenate dehydratase 1 form all of or part of a signal transduction mechanism responsible for the light-mediated synthesis of phenylpyruvate and phenylalanine.
      Title: G-protein-coupled receptor 1, G-protein Galpha-subunit 1, and prephenate dehydratase 1 are required for blue light-induced production of phenylalanine in etiolated Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001333320.1
    NM_103724.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-phenylalanine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in blue light signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in brassinosteroid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gibberellic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of inositol trisphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cytokinin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to low fluence blue light stimulus by blue low-fluence system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tyrosine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G-protein-coupled receptor 1
    NP_175261.1
    • G-protein-coupled receptor 1 (GCR1); FUNCTIONS IN: G-protein coupled receptor activity; INVOLVED IN: in 7 processes; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: G-protein-coupled receptor, GCR1 putative (InterPro:IPR022340), GPCR, family 2-like (InterPro:IPR017981), GCR1-cAMP receptor (InterPro:IPR022343); Has 592 Blast hits to 590 proteins in 111 species: Archae - 0; Bacteria - 0; Metazoa - 324; Fungi - 88; Plants - 42; Viruses - 0; Other Eukaryotes - 138 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      17827953..17830420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103724.2 → NP_175261.1  G-protein-coupled receptor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175261.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04214, O04714, Q8LPG0
      UniProtKB/TrEMBL
      A0A178WGM3
      Conserved Domains (2) summary
      cd14964
      Location:48 → 70
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:26 → 272
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001333320.1 → NP_001321802.1  G-protein-coupled receptor 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04214, O04714, Q8LPG0
      UniProtKB/TrEMBL
      A0A178WGM3
      Conserved Domains (2) summary
      cd14964
      Location:48 → 70
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:26 → 272
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04714.1

    Gene LinkOut

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