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    CIPK9 CBL-interacting protein kinase 9 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839349, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CIPK9
    Official Full Name
    CBL-interacting protein kinase 9
    Primary source
    TAIR:AT1G01140
    Locus tag
    AT1G01140
    See related
    Araport:AT1G01140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CBL-interacting protein kinase 9; F6F3.28; PKS6; PROTEIN KINASE 6; SNF1-RELATED PROTEIN KINASE 3.12; SnRK3.12
    Summary
    Encodes a CBL-interacting protein kinase with similarity to SOS2
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    Genomic context

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    See CIPK9 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Sequence:
    Chromosome: 1; NC_003070.9 (64166..67774, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene 3-ketoacyl-CoA synthase 1 Neighboring gene CBL-interacting Serine/Threonine-kinase Neighboring gene Homeodomain-like protein with RING/FYVE/PHD-type zinc finger domain-containing protein Neighboring gene ncRNA Neighboring gene GRF1-interacting factor 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis calcineurin B-like proteins differentially regulate phosphorylation activity of CBL-interacting protein kinase 9. Yadav AK, et al. Biochem J, 2018 Aug 30. PMID 30054434
    2. CIPK9: a calcium sensor-interacting protein kinase required for low-potassium tolerance in Arabidopsis. Pandey GK, et al. Cell Res, 2007 May. PMID 17486125
    3. CIPK9 targets VDAC3 and modulates oxidative stress responses in Arabidopsis. Kanwar P, et al. Plant J, 2022 Jan. PMID 34748255
    4. A protein phosphatase 2C, AP2C1, interacts with and negatively regulates the function of CIPK9 under potassium-deficient conditions in Arabidopsis. Singh A, et al. J Exp Bot, 2018 Jul 18. PMID 29767755, Free PMC Article
    5. Arabidopsis K+ transporter HAK5-mediated high-affinity root K+ uptake is regulated by protein kinases CIPK1 and CIPK9. Lara A, et al. J Exp Bot, 2020 Aug 6. PMID 32484219, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CIPK9 targets VDAC3 and modulates oxidative stress responses in Arabidopsis.
      Title: CIPK9 targets VDAC3 and modulates oxidative stress responses in Arabidopsis.
    2. Arabidopsis K+ transporter HAK5-mediated high-affinity root K+ uptake is regulated by protein kinases CIPK1 and CIPK9.
      Title: Arabidopsis K+ transporter HAK5-mediated high-affinity root K+ uptake is regulated by protein kinases CIPK1 and CIPK9.
    3. study shows that AP2C1 and CIPK9 interact to regulate K+-deficiency responses in Arabidopsis. CIPK9 functions as positive regulator whereas AP2C1 acts as a negative regulator of Arabidopsis root growth and seedling development under low-K+ conditions
      Title: A protein phosphatase 2C, AP2C1, interacts with and negatively regulates the function of CIPK9 under potassium-deficient conditions in Arabidopsis.
    4. study suggests that CIPK9 differentially phosphorylates interacting CBLs, and furthermore, the kinase activity of CIPK9 is also differentially regulated by specific interacting CBLs.
      Title: Arabidopsis calcineurin B-like proteins differentially regulate phosphorylation activity of CBL-interacting protein kinase 9.
    5. CBL3 and CIPK9 regulates potassium homeostasis under low potassium stress.
      Title: A protein kinase, calcineurin B-like protein-interacting protein Kinase9, interacts with calcium sensor calcineurin B-like Protein3 and regulates potassium homeostasis under low-potassium stress in Arabidopsis.
    6. CIPK9 gene was responsive to abiotic stress conditions, and its transcript was inducible in both roots and shoots by potassium deprivation. Disruption of CIPK9 function rendered the mutant plants hypersensitive to low potassium media.
      Title: CIPK9: a calcium sensor-interacting protein kinase required for low-potassium tolerance in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_099996.4
    NM_179239.1
    NM_179240.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to potassium ion starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to mannitol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CBL-interacting protein kinase 9
    NP_171622.1
    • CBL-interacting protein kinase 9 (CIPK9); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: in 6 processes; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), CBL-interacting protein kinase (InterPro:IPR020660), NAF domain (InterPro:IPR004041), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: CBL-interacting protein kinase 23 (TAIR:AT1G30270.1); Has 130203 Blast hits to 128118 proteins in 4349 species: Archae - 165; Bacteria - 15262; Metazoa - 47961; Fungi - 13206; Plants - 31482; Viruses - 522; Other Eukaryotes - 21605 (source: NCBI BLink).
    NP_849570.1
    • CBL-interacting protein kinase 9 (CIPK9); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: in 6 processes; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), NAF domain (InterPro:IPR004041), CBL-interacting protein kinase (InterPro:IPR020660), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: CBL-interacting protein kinase 23 (TAIR:AT1G30270.1); Has 130491 Blast hits to 128500 proteins in 4421 species: Archae - 165; Bacteria - 15543; Metazoa - 48035; Fungi - 13165; Plants - 31462; Viruses - 522; Other Eukaryotes - 21599 (source: NCBI BLink).
    NP_849571.1
    • CBL-interacting protein kinase 9 (CIPK9); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: in 6 processes; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), NAF domain (InterPro:IPR004041), CBL-interacting protein kinase (InterPro:IPR020660), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: CBL-interacting protein kinase 23 (TAIR:AT1G30270.1); Has 130572 Blast hits to 128490 proteins in 4426 species: Archae - 165; Bacteria - 15544; Metazoa - 48044; Fungi - 13206; Plants - 31490; Viruses - 522; Other Eukaryotes - 21601 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      64166..67774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_099996.4 → NP_171622.1  CBL-interacting protein kinase 9 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171622.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EDL5, Q94F03, Q9C5P5, Q9C5S4, Q9MAM1
      UniProtKB/TrEMBL
      A0A178W7T6, A0A7G2DPR6
      Conserved Domains (2) summary
      cd12195
      Location:318 → 433
      CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases
      cd14663
      Location:19 → 273
      STKc_SnRK3; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3

    2. NM_179240.1 → NP_849571.1  CBL-interacting protein kinase 9 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849571.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2DPR6
      Conserved Domains (3) summary
      cd12195
      Location:318 → 437
      CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases
      smart00220
      Location:19 → 274
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14663
      Location:19 → 273
      STKc_SnRK3; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3

    3. NM_179239.1 → NP_849570.1  CBL-interacting protein kinase 9 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2DPR6
      Conserved Domains (3) summary
      cd12195
      Location:320 → 435
      CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases
      smart00220
      Location:19 → 276
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14663
      Location:19 → 275
      STKc_SnRK3; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9MAM1.2

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