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    HMGB3 high mobility group B3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838659, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HMGB3
    Official Full Name
    high mobility group B3
    Primary source
    TAIR:AT1G20696
    Locus tag
    AT1G20696
    See related
    Araport:AT1G20696
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    high mobility group B3; NFD03; NFD3; NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR
    Summary
    Encodes a protein belonging to the subgroup of HMGB (high mobility group B) proteins that have a distinctive DNA-binding motif, the HMG-box domain. The motif confers non-sequence specific interaction with linear DNA and structure-specific binding to distorted DNA sites. The HMGB proteins are involved in the assembly of nucleoprotein complexes. Can be phosphorylated by CK2alpha.
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    Genomic context

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    See HMGB3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (7179273..7181574)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SWI-SNF-related chromatin binding protein Neighboring gene ncRNA Neighboring gene high mobility group B2 Neighboring gene WUSCHEL related homeobox 14 Neighboring gene WUSCHEL related homeobox 10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleocytoplasmic distribution of the Arabidopsis chromatin-associated HMGB2/3 and HMGB4 proteins. Pedersen DS, et al. Plant Physiol, 2010 Dec. PMID 20940346, Free PMC Article
    2. Phosphorylation of maize and Arabidopsis HMGB proteins by protein kinase CK2alpha. Stemmer C, et al. Biochemistry, 2003 Apr 1. PMID 12653554
    3. Variability in Arabidopsis thaliana chromosomal high-mobility-group-1-like proteins. Stemmer C, et al. Eur J Biochem, 1997 Dec 15. PMID 9461286
    4. Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis. Saracco SA, et al. Plant J, 2009 Jul. PMID 19292762, Free PMC Article
    5. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001035998.1
    NM_001084101.2
    NM_001332459.1
    NM_101921.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables chromatin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables structural constituent of chromatin TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chromatin TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    high mobility group B3
    NP_001031075.1
    • high mobility group B3 (HMGB3); FUNCTIONS IN: chromatin binding, structural constituent of chromatin, DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: chromatin assembly or disassembly; LOCATED IN: chromatin; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: High mobility group, superfamily (InterPro:IPR009071), High mobility group, HMG1/HMG2 (InterPro:IPR000910); BEST Arabidopsis thaliana protein match is: high mobility group B2 (TAIR:AT1G20693.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001077570.2
    • high mobility group B3 (HMGB3); FUNCTIONS IN: chromatin binding, structural constituent of chromatin, DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: chromatin assembly or disassembly; LOCATED IN: chromatin; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: High mobility group, superfamily (InterPro:IPR009071), High mobility group, HMG1/HMG2 (InterPro:IPR000910); BEST Arabidopsis thaliana protein match is: high mobility group B2 (TAIR:AT1G20693.2); Has 5742 Blast hits to 4932 proteins in 507 species: Archae - 0; Bacteria - 0; Metazoa - 4274; Fungi - 383; Plants - 553; Viruses - 0; Other Eukaryotes - 532 (source: NCBI BLink).
    NP_564124.1
    • high mobility group B3 (HMGB3); FUNCTIONS IN: chromatin binding, structural constituent of chromatin, DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: chromatin assembly or disassembly; LOCATED IN: chromatin; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: High mobility group, superfamily (InterPro:IPR009071), High mobility group, HMG1/HMG2 (InterPro:IPR000910); BEST Arabidopsis thaliana protein match is: high mobility group B2 (TAIR:AT1G20693.2); Has 5914 Blast hits to 5088 proteins in 514 species: Archae - 0; Bacteria - 0; Metazoa - 4343; Fungi - 437; Plants - 569; Viruses - 4; Other Eukaryotes - 561 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      7179273..7181574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001332458.1 → NP_001322267.1  high mobility group B3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ATJ7

    2. NM_101921.4 → NP_564124.1  high mobility group B3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564124.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MQS4, P93047, Q2L6T4
      UniProtKB/TrEMBL
      A0A178W6Y6
      Conserved Domains (1) summary
      pfam00505
      Location:35 → 103
      HMG_box; HMG (high mobility group) box

    3. NM_001332459.1 → NP_001322266.1  high mobility group B3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ATG5

    4. NM_001035998.1 → NP_001031075.1  high mobility group B3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031075.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9VCC0, A0A654ECM5
      Conserved Domains (1) summary
      cd01390
      Location:35 → 101
      HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...

    5. NM_001084101.2 → NP_001077570.2  high mobility group B3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2H1ZEC3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P93047.1

    Gene LinkOut

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