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    Bambi BMP and activin membrane-bound inhibitor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83837, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Bambiprovided by RGD
    Official Full Name
    BMP and activin membrane-bound inhibitorprovided by RGD
    Primary source
    RGD:621831
    See related
    EnsemblRapid:ENSRNOG00000016066 AllianceGenome:RGD:621831
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable frizzled binding activity. Involved in transforming growth factor beta receptor signaling pathway. Predicted to be located in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human BAMBI (BMP and activin membrane bound inhibitor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 227.8), Lung (RPKM 138.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bambi in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (58816438..58821003, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (54121251..54125816, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (56905419..56909675, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482859 Neighboring gene uncharacterized LOC102552678 Neighboring gene RIKEN cDNA 4930596D02 gene like 2 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene cullin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury. Yang Y, et al. Int J Mol Med, 2017 Feb. PMID 28035406
    2. Expression of Bambi is widespread in juvenile and adult rat tissues and is regulated in male germ cells. Loveland KL, et al. Endocrinology, 2003 Sep. PMID 12933693
    3. Angiotensin II facilitates fibrogenic effect of TGF-β1 through enhancing the down-regulation of BAMBI caused by LPS: a new pro-fibrotic mechanism of angiotensin II. Li YS, et al. PLoS One, 2013. PMID 24155898, Free PMC Article
    4. [Distribution and mRNA Expression of BAMBI in Non-small-cell Lung Cancer.]. Miao S, et al. Zhongguo Fei Ai Za Zhi, 2009 Mar 20. PMID 20716422
    5. Lipopolysaccharide enhances TGF-β1 signalling pathway and rat pancreatic fibrosis. Sun L, et al. J Cell Mol Med, 2018 Apr. PMID 29424488, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of circDNMT3B contributes to vascular dysfunction in diabetic retinas through regulating miR-20b-5p and BAMBI, providing a potential treatment strategy for diabetic retinopathy
      Title: Downregulation of circRNA DMNT3B contributes to diabetic retinal vascular dysfunction through targeting miR-20b-5p and BAMBI.
    2. These findings indicate that LPS increases TGF-beta1 production through paracrine and autocrine mechanisms and that LPS enhances TGF-beta1 signalling in PSCs by repressing BAMBI via TLR4/MyD88/NF-kB activation.
      Title: Lipopolysaccharide enhances TGF-β1 signalling pathway and rat pancreatic fibrosis.
    3. BAMBI plays a neuroprotective role by decreasing inflammation and activating autophagy in rats with SCI.
      Title: BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury.
    4. Angiotensin II enhances lipopolysaccharide-TLR4 pathway signaling and further down-regulates expression of BAMBI through up-regulation of TLR4, which results in facilitation of pro-fibrotic activity of TGF-beta1.
      Title: Angiotensin II facilitates fibrogenic effect of TGF-β1 through enhancing the down-regulation of BAMBI caused by LPS: a new pro-fibrotic mechanism of angiotensin II.
    5. Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/beta-catenin signaling
      Title: Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling.
    6. Regulated Bambi mRNA synthesis may contribute to TGF beta superfamily signaling modulation in several organs, as suggested by its discrete expression switch in male germ cells.
      Title: Expression of Bambi is widespread in juvenile and adult rat tissues and is regulated in male germ cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables frizzled binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BMP and activin membrane-bound inhibitor homolog
    Names
    BMP and activin membrane-bound inhibitor, homolog
    kinase-deficient TGFbeta superfamily receptor subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139082.3 → NP_620782.1  BMP and activin membrane-bound inhibitor homolog precursor

      See identical proteins and their annotated locations for NP_620782.1

      Status: PROVISIONAL

      Source sequence(s)
      AF387513
      UniProtKB/Swiss-Prot
      Q91XN4
      UniProtKB/TrEMBL
      A6K9G6
      Related
      ENSRNOP00000021801.3, ENSRNOT00000021801.7
      Conserved Domains (1) summary
      pfam06211
      Location:4 → 111
      BAMBI; BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      58816438..58821003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096114.2 → XP_038952042.1  BMP and activin membrane-bound inhibitor homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABP7
      Related
      ENSRNOP00000090807.1, ENSRNOT00000105136.2
      Conserved Domains (1) summary
      pfam06211
      Location:8 → 95
      BAMBI; BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XN4.1 GenPept UniProtKB/Swiss-Prot:Q91XN4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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