Slc26a5 solute carrier family 26 member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc26a5provided by RGD
Official Full Name: solute carrier family 26 member 5provided by RGD
Primary source: RGD:69334
See related: EnsemblRapid:ENSRNOG00000011616 AllianceGenome:RGD:69334
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pres; prestin
Summary: Enables chloride:bicarbonate antiporter activity and identical protein binding activity. Involved in several processes, including bicarbonate transport; chloride transmembrane transport; and positive regulation of cell size. Located in basolateral plasma membrane and lateral plasma membrane. Biomarker of hypothyroidism. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 61. Orthologous to human SLC26A5 (solute carrier family 26 member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 17.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q11

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (14102492..14141520)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (13210260..13249289)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (9795811..9860904)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Calmodulin binds to the STAS domain of SLC26A5 prestin with a calcium-dependent, one-lobe, binding mode.
Title: Calmodulin binds to the STAS domain of SLC26A5 prestin with a calcium-dependent, one-lobe, binding mode.
These results suggest that there is a temporal pattern of change in serum prestin level after noise-induced hearing loss that is related to severity of hearing loss. Circulatory levels of prestin may be able to act as surrogate biomarker for hearing loss involving outer hair cell loss.
Title: Noise-induced trauma produces a temporal pattern of change in blood levels of the outer hair cell biomarker prestin.
work, for the first time, provides proof of concept that the levels of prestin, an otologic serum biomarker, can change after acoustic trauma and hearing loss
Title: Outer Hair Cell Molecular Protein, Prestin, as a Serum Biomarker for Hearing Loss: Proof of Concept.
Prestin expression first appeared at postnatal day 6 (P6) in the auditory brainstem and reached mature level by P14.
Title: Synchronized Progression of Prestin Expression and Auditory Brainstem Response during Postnatal Development in Rats.
Molecular dynamics simulations of the STAS domains of rat prestin and human pendrin reveal conformational motions in conserved flexible regions.
Title: Molecular dynamics simulations of the STAS domains of rat prestin and human pendrin reveal conformational motions in conserved flexible regions.
in chicken STAS, the anion-binding site is lacking because of a local structural rearrangement, indicating that the presence of the STAS anion-binding site is exclusive to mammalian prestin
Title: The STAS domain of mammalian SLC26A5 prestin harbours an anion-binding site.
The findings suggest that CASK and the truncated prestin splice isoform contribute to confinement of prestin to the basolateral region of the plasma membrane.
Title: Generation of somatic electromechanical force by outer hair cells may be influenced by prestin-CASK interaction at the basal junction with the Deiter's cell.
prestin can transport bicarbonate at low rates and acts as an electrogenic transporter for chloride
Title: Mammalian prestin is a weak Cl⁻/HCO₃⁻ electrogenic antiporter.
Chronic depolarization decreases prestin expression and possibly contributes to hearing loss and tinnitus.
Title: Decrease of prestin expression by increased potassium concentration in organotypic cultures of the organ of Corti of newborn rats.
Data suggest that Brn-3c, C/ebpb, and Carf contribute to regulating the expression of prestin.
Title: Expression analysis of prestin and selected transcription factors in newborn rats.

Submit: New GeneRIF Correction See all GeneRIFs (22)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bicarbonate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride:bicarbonate antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables cytoskeletal motor activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables monoatomic anion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables oxalate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables secondary active sulfate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in bicarbonate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloride transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cochlea development	IEP Inferred from Expression Pattern more info	PubMed
involved_in fructose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in inorganic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic anion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of monoatomic ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in oxalate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell motility	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell size	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in response to auditory stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ischemia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to potassium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salicylic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salt	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to thyroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sensory perception of sound	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sulfate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfate transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral wall of outer hair cell	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: prestin

Names: prestin (motor protein); solute carrier family 26 (anion exchanger), member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030840.1 → NP_110467.1 prestin

See identical proteins and their annotated locations for NP_110467.1

Status: PROVISIONAL

Source sequence(s)

AJ303372

UniProtKB/Swiss-Prot

Q9EPH0, Q9ERC6

UniProtKB/TrEMBL

A0A8I6A1V5, A6K5A0

Related

ENSRNOP00000015733.2, ENSRNOT00000015733.4

Conserved Domains (3) summary

cd07042
Location:526 → 694

STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function

TIGR00815
Location:66 → 709

sulP; high affinity sulphate transporter 1

pfam01740
Location:589 → 683

STAS; STAS domain