ZWI kinesin-like calmodulin-binding protein (ZWICHEL) [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ZWI
Official Full Name: kinesin-like calmodulin-binding protein (ZWICHEL)
Primary source: TAIR:AT5G65930
Locus tag: AT5G65930
See related: Araport:AT5G65930
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: K14B20.10; K14B20_10; KCBP; KINESIN-LIKE CALMODULIN-BINDING PROTEIN; PKCBP; POTATO KINESIN-LIKE CALMODULIN-BINDING PROTEIN; ZWICHEL
Summary: encodes a novel member of the kinesin superfamily of motor proteins. recessive mutations have reduced number of trichome branches.
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Genomic context

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See ZWI in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 22

Sequence:: Chromosome: 5; NC_003076.8 (26369857..26376572, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results suggest that KCBP binds to non-membranous naked chromosomes via an unidentified protein(s) for their transport.
Title: Moss Kinesin-14 KCBP Accelerates Chromatid Motility in Anaphase.
our findings define a novel genetic and molecular mechanism by which TCS1 interacts with KCBP to regulate trichome cell shape by influencing the stability of microtubules.
Title: TCS1, a Microtubule-Binding Protein, Interacts with KCBP/ZWICHEL to Regulate Trichome Cell Shape in Arabidopsis thaliana.
The MyTH4 domain and the FERM domain in the N-terminal tail of KCBP physically bind to microtubules and F-actin, respectively.
Title: Orchestration of microtubules and the actin cytoskeleton in trichome cell shape determination by a plant-unique kinesin.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001203699.1

Supported by ESTs:

NM_125990.4

Supported by ESTs:

NM_180945.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	TAS Traceable Author Statement more info	PubMed
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	TAS Traceable Author Statement more info	PubMed
enables minus-end-directed microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cortical microtubule organization	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule bundle formation	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule-based movement	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pollen germination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within trichome branching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trichome branching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trichome patterning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cortical microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in phragmoplast	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kinesin-like calmodulin-binding protein (ZWICHEL)

NP_001190628.1

ZWICHEL (ZWI); CONTAINS InterPro DOMAIN/s: FERM central domain (InterPro:IPR019748), Prismane-like (InterPro:IPR011254), MyTH4 domain (InterPro:IPR000857), Kinesin, motor domain (InterPro:IPR001752), Band 4.1 domain (InterPro:IPR019749), FERM, N-terminal (InterPro:IPR018979), Kinesin, motor region, conserved site (InterPro:IPR019821), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352), FERM domain (InterPro:IPR000299); BEST Arabidopsis thaliana protein match is: Di-glucose binding protein with Kinesin motor domain (TAIR:AT2G22610.2).

NP_569022.2

ZWICHEL (ZWI); FUNCTIONS IN: microtubule motor activity, calmodulin binding; INVOLVED IN: trichome branching, pollen germination; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: FERM central domain (InterPro:IPR019748), Prismane-like (InterPro:IPR011254), MyTH4 domain (InterPro:IPR000857), Kinesin, motor domain (InterPro:IPR001752), FERM, N-terminal (InterPro:IPR018979), Band 4.1 domain (InterPro:IPR019749), Kinesin, motor region, conserved site (InterPro:IPR019821), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352), FERM domain (InterPro:IPR000299); BEST Arabidopsis thaliana protein match is: Di-glucose binding protein with Kinesin motor domain (TAIR:AT2G22610.1); Has 92267 Blast hits to 53660 proteins in 2386 species: Archae - 1115; Bacteria - 10663; Metazoa - 44616; Fungi - 7060; Plants - 5081; Viruses - 192; Other Eukaryotes - 23540 (source: NCBI BLink).

NP_851276.1

ZWICHEL (ZWI); FUNCTIONS IN: microtubule motor activity, calmodulin binding; INVOLVED IN: trichome branching, pollen germination; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: FERM central domain (InterPro:IPR019748), Prismane-like (InterPro:IPR011254), MyTH4 domain (InterPro:IPR000857), Kinesin, motor domain (InterPro:IPR001752), FERM, N-terminal (InterPro:IPR018979), Band 4.1 domain (InterPro:IPR019749), Kinesin, motor region, conserved site (InterPro:IPR019821), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352), FERM domain (InterPro:IPR000299); BEST Arabidopsis thaliana protein match is: Di-glucose binding protein with Kinesin motor domain (TAIR:AT2G22610.1); Has 92234 Blast hits to 53602 proteins in 2354 species: Archae - 1118; Bacteria - 10667; Metazoa - 44581; Fungi - 7061; Plants - 5079; Viruses - 192; Other Eukaryotes - 23536 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

26369857..26376572 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125990.4 → NP_569022.2 kinesin-like calmodulin-binding protein (ZWICHEL) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_569022.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O22326, O23102, Q0WM77, Q39130, Q8VZV4, Q9FHN8

UniProtKB/TrEMBL

A0A178UBS0, A0A5S9YHC7, A0A654GET6

Conserved Domains (5) summary

smart00139
Location:115 → 274

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:283 → 499

B41; Band 4.1 homologues

COG1196
Location:620 → 890

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd13200
Location:496 → 602

FERM_C_KCBP; FERM domain C-lobe of Kinesin-like calmodulin binding protein

cd01366
Location:886 → 1211

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
NM_180945.2 → NP_851276.1 kinesin-like calmodulin-binding protein (ZWICHEL) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_851276.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A654GET6

Conserved Domains (8) summary

smart00129
Location:888 → 1215

KISc; Kinesin motor, catalytic domain. ATPase

smart00139
Location:115 → 274

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:283 → 498

B41; Band 4.1 homologues

cd13200
Location:495 → 601

FERM_C_KCBP; FERM domain C-lobe of Kinesin-like calmodulin binding protein

cd01366
Location:885 → 1210

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

pfam00373
Location:395 → 499

FERM_M; FERM central domain

pfam09379
Location:283 → 356

FERM_N; FERM N-terminal domain

pfam16796
Location:869 → 894

Microtub_bd; Microtubule binding
NM_001203699.1 → NP_001190628.1 kinesin-like calmodulin-binding protein (ZWICHEL) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190628.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A654GET6, F4JXM5

Conserved Domains (8) summary

smart00129
Location:895 → 1222

KISc; Kinesin motor, catalytic domain. ATPase

smart00139
Location:121 → 280

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:289 → 505

B41; Band 4.1 homologues

cd13200
Location:502 → 608

FERM_C_KCBP; FERM domain C-lobe of Kinesin-like calmodulin binding protein

cd01366
Location:892 → 1217

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

pfam00373
Location:402 → 506

FERM_M; FERM central domain

pfam09379
Location:289 → 363

FERM_N; FERM N-terminal domain

pfam16796
Location:876 → 901

Microtub_bd; Microtubule binding