ABCB25 ABC transporter of the mitochondrion 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ABCB25
Official Full Name: ABC transporter of the mitochondrion 3
Primary source: TAIR:AT5G58270
Locus tag: AT5G58270
See related: Araport:AT5G58270
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ABC transporter of the mitochondrion 3; ARABIDOPSIS THALIANA ABC TRANSPORTER OF THE MITOCHONDRION 3; ATATM3; ATM3; ATP-binding cassette B25; HALF-MOLECULE ABC TRANSPORTER ATM3; MCK7.14; MCK7_14; STA1; STARIK 1
Summary: Encodes a mitochondrial half-molecule ABC transporter, a member of ATM subfamily. Mutants are dwarfed, chlorotic plants with altered leaf morphology. ATM3 transcription is induced by Cd(II) or Pb(II). Involved in heavy metal resistance. Arabidopsis thaliana has three ATM genes, namely ATM1, ATM2 and ATM3. Only ATM3 has an important function for plant growth. Role in Moco biosynthesis.
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Genomic context

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See ABCB25 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 18

Sequence:: Chromosome: 5; NC_003076.8 (23561890..23567244)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STABILIZED1 is a heat stress-specific splicing factor in Arabidopsis thaliana
Title: STABILIZED1 as a heat stress-specific splicing factor in Arabidopsis thaliana.
The data functionally characterize CNX2 and suggest that ATM3 is indirectly required for cyclic pyranopterin monophosphate biosynthesis.
Title: Genetic dissection of cyclic pyranopterin monophosphate biosynthesis in plant mitochondria.
growth phenotype of atm3-1 was strongly enhanced by depletion of the mitochondrion-localized, GSH-dependent persulfide oxygenase ETHE1, suggesting that the physiological substrate of ATM3 contains persulfide in addition to glutathione
Title: A conserved mitochondrial ATP-binding cassette transporter exports glutathione polysulfide for cytosolic metal cofactor assembly.
Arabidopsis ATM3 may transport (1) at least two distinct compounds or (2) a single compound required for both Fe-S and molybdenum cofactor assembly machineries in the cytosol, but not iron.
Title: An allelic mutant series of ATM3 reveals its key role in the biogenesis of cytosolic iron-sulfur proteins in Arabidopsis.
Results show that STABILIZED1 (STA1) is a pre-mRNA splicing factor required not only for splicing but also for the turnover of unstable transcripts and that it has an important role in plant responses to abiotic stresses.
Title: STABILIZED1, a stress-upregulated nuclear protein, is required for pre-mRNA splicing, mRNA turnover, and stress tolerance in Arabidopsis.
AtATM3 contributes to heavy metal resistance and it may mediate transport of glutamine synthetase-conjugated Cd(II) across the mitochondrial membrane in Arabidopis.
Title: AtATM3 is involved in heavy metal resistance in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_125212.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chloroplast organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular iron ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of chlorophyll biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to cadmium ion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to lead ion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast envelope	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: ABC transporter of the mitochondrion 3

NP_200635.1

ABC transporter of the mitochondrion 3 (ATM3); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances, transporter activity; INVOLVED IN: in 9 processes; LOCATED IN: mitochondrion, chloroplast, chloroplast envelope; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: ABC transporter of the mitochondrion 1 (TAIR:AT4G28630.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

23561890..23567244

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125212.3 → NP_200635.1 ABC transporter of the mitochondrion 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_200635.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LF78, Q9LVM1

UniProtKB/TrEMBL

A0A178UMV6, A0A5S9YF55, A0A654GC21

Conserved Domains (1) summary

COG5265
Location:218 → 713

ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]