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    TAP46 2A phosphatase associated protein of 46 kD [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835379, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TAP46
    Official Full Name
    2A phosphatase associated protein of 46 kD
    Primary source
    TAIR:AT5G53000
    Locus tag
    AT5G53000
    See related
    Araport:AT5G53000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    2A phosphatase associated protein of 46 kD; MNB8.6; MNB8_6
    Summary
    PP2A-associated protein with a possible function in the chilling response
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    Genomic context

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    See TAP46 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (21485317..21488042, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene egg cell-secreted-like protein (DUF1278) Neighboring gene ER-based factor for assembly of V-ATPase Neighboring gene SNARE-like superfamily protein Neighboring gene calcium-transporting ATPase Neighboring gene Ribonuclease P protein subunit P38-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis homolog of yeast TAP42 and mammalian alpha4 binds to the catalytic subunit of protein phosphatase 2A and is induced by chilling. Harris DM, et al. Plant Physiol, 1999 Oct. PMID 10517853, Free PMC Article
    2. Overexpression of the PP2A regulatory subunit Tap46 leads to enhanced plant growth through stimulation of the TOR signalling pathway. Ahn CS, et al. J Exp Bot, 2015 Feb. PMID 25399018, Free PMC Article
    3. The PP2A regulatory subunit Tap46, a component of the TOR signaling pathway, modulates growth and metabolism in plants. Ahn CS, et al. Plant Cell, 2011 Jan. PMID 21216945, Free PMC Article
    4. TAP46 plays a positive role in the ABSCISIC ACID INSENSITIVE5-regulated gene expression in Arabidopsis. Hu R, et al. Plant Physiol, 2014 Feb. PMID 24357600, Free PMC Article
    5. Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase. Van Leene J, et al. Nat Plants, 2019 Mar. PMID 30833711

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of TAP46 and inhibition of activities of PP2A or PP2A-like protein phosphatases can increase transcript levels of several ABI5-regulated genes.
      Title: TAP46 plays a positive role in the ABSCISIC ACID INSENSITIVE5-regulated gene expression in Arabidopsis.
    2. Tap46 plays an essential role in the regulation of plant cell growth and metabolism through a functional link with TOR.
      Title: The PP2A regulatory subunit Tap46, a component of the TOR signaling pathway, modulates growth and metabolism in plants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_124679.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nitrogen utilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to abscisic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    NOT involved_in response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    2A phosphatase associated protein of 46 kD
    NP_568783.1
    • 2A phosphatase associated protein of 46 kD (TAP46); CONTAINS InterPro DOMAIN/s: TAP42-like protein (InterPro:IPR007304); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      21485317..21488042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124679.3 → NP_568783.1  2A phosphatase associated protein of 46 kD [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568783.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LDQ4, Q9LVV2, Q9XHD0
      UniProtKB/TrEMBL
      A0A5S9YDS1, A0A654GBG2
      Conserved Domains (1) summary
      pfam04177
      Location:11 → 392
      TAP42; TAP42-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LDQ4.2

    Gene LinkOut

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