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    AAP6 amino acid permease 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835025, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AAP6
    Official Full Name
    amino acid permease 6
    Primary source
    TAIR:AT5G49630
    Locus tag
    AT5G49630
    See related
    Araport:AT5G49630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    amino acid permease 6; MNI5.1; MNI5_1
    Summary
    Is a high affinity amino acid transporter capable of transporting aspartate and tryptophan. May be involved in the amino acid uptake from xylem.
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    Genomic context

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    See AAP6 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (20142430..20146690, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene myb domain protein 78 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene xylulose kinase-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mutation in amino acid permease AAP6 reduces the amino acid content of the Arabidopsis sieve elements but leaves aphid herbivores unaffected. Hunt E, et al. J Exp Bot, 2010. PMID 19755569, Free PMC Article
    2. The amino acid permeases AAP3 and AAP6 are involved in root-knot nematode parasitism of Arabidopsis. Marella HH, et al. Mol Plant Microbe Interact, 2013 Jan. PMID 23194341
    3. Low and high affinity amino acid H+-cotransporters for cellular import of neutral and charged amino acids. Fischer WN, et al. Plant J, 2002 Mar. PMID 12148530
    4. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
    5. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRISPR/Cas9-induced knockout of an amino acid permease gene (AAP6) reduced Arabidopsis thaliana susceptibility to Meloidogyne incognita.
      Title: CRISPR/Cas9-induced knockout of an amino acid permease gene (AAP6) reduced Arabidopsis thaliana susceptibility to Meloidogyne incognita.
    2. The transport of amino acids by AAP3 and AAP6 is important for nematode infection and success of the progeny.
      Title: The amino acid permeases AAP3 and AAP6 are involved in root-knot nematode parasitism of Arabidopsis.
    3. The total amino acid concentration of SE sap of the aap6 mutant plants was significantly lower than that of the wild-type plants.
      Title: A mutation in amino acid permease AAP6 reduces the amino acid content of the Arabidopsis sieve elements but leaves aphid herbivores unaffected.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_124341.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables acidic amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within aspartate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within tryptophan transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    amino acid permease 6
    NP_199774.1
    • amino acid permease 6 (AAP6); FUNCTIONS IN: acidic amino acid transmembrane transporter activity, neutral amino acid transmembrane transporter activity, amino acid transmembrane transporter activity; INVOLVED IN: response to water deprivation, response to salt stress, aspartate transport, tryptophan transport; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Amino acid transporter, transmembrane (InterPro:IPR013057); BEST Arabidopsis thaliana protein match is: amino acid permease 1 (TAIR:AT1G58360.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      20142430..20146690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124341.4 → NP_199774.1  amino acid permease 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199774.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P92934
      UniProtKB/TrEMBL
      A0A178UHU7, A0A5S9YCT9, A0A654GA18
      Conserved Domains (1) summary
      pfam01490
      Location:33 → 470
      Aa_trans; Transmembrane amino acid transporter protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P92934.1

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