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    DFR dihydroflavonol 4-reductase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834291, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DFR
    Official Full Name
    dihydroflavonol 4-reductase
    Primary source
    TAIR:AT5G42800
    Locus tag
    AT5G42800
    See related
    Araport:AT5G42800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    dihydroflavonol 4-reductase; DIHYDROFLAVONOL 4-REDUCTASE; DIHYDROKAEMPFEROL 4-REDUCTASE; M318; MJB21.18; MJB21_18; TT3
    Summary
    dihydroflavonol reductase. Catalyzes the conversion of dihydroquercetin to leucocyanidin in the biosynthesis of anthocyanins. Not expressed in roots (qRT-PCR).
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    Genomic context

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    See DFR in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (17164093..17166032, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene proteasome alpha subunit F1 Neighboring gene low-molecular-weight cysteine-rich 28 Neighboring gene inositol-pentakisphosphate 2-kinase 1 Neighboring gene Zinc finger C-x8-C-x5-C-x3-H type family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of Flavonoid Biosynthetic Genes in Germinating Arabidopsis Seedlings. Kubasek WL, et al. Plant Cell, 1992 Oct. PMID 12297632, Free PMC Article
    2. The miR156-SPL9-DFR pathway coordinates the relationship between development and abiotic stress tolerance in plants. Cui LG, et al. Plant J, 2014 Dec. PMID 25345491
    3. Förster resonance energy transfer demonstrates a flavonoid metabolon in living plant cells that displays competitive interactions between enzymes. Crosby KC, et al. FEBS Lett, 2011 Jul 21. PMID 21669202
    4. Interactions among enzymes of the Arabidopsis flavonoid biosynthetic pathway. Burbulis IE, et al. Proc Natl Acad Sci U S A, 1999 Oct 26. PMID 10536025, Free PMC Article
    5. Effects of ionizing radiation on a plant genome: analysis of two Arabidopsis transparent testa mutations. Shirley BW, et al. Plant Cell, 1992 Mar. PMID 1354004, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_123645.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables dihydrokaempferol 4-reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables dihydrokaempferol 4-reductase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables flavanone 4-reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anthocyanin-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within anthocyanin-containing compound biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within anthocyanin-containing compound biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dihydroflavonol 4-reductase
    NP_199094.1
    • dihydroflavonol 4-reductase (DFR); CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT2G45400.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      17164093..17166032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123645.4 → NP_199094.1  dihydroflavonol 4-reductase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199094.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P51102, Q9FEB1
      UniProtKB/TrEMBL
      A0A5S9YAQ0, A0A654G7W7, B1GV15, B1GV31, Q56XQ1
      Conserved Domains (1) summary
      PLN02650
      Location:1 → 349
      PLN02650; dihydroflavonol-4-reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51102.2

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