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    GME GDP-D-mannose 3',5'-epimerase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833002, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GME
    Official Full Name
    GDP-D-mannose 3',5'-epimerase
    Primary source
    TAIR:AT5G28840
    Locus tag
    AT5G28840
    See related
    Araport:AT5G28840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''GDP-D-mannose 3'; 5'-epimerase; 5'-epimerase''; F7P1.20; F7P1_20; GDP-D-mannose 3'
    Summary
    Encodes a protein with GDP-D-mannose 3',5'-epimerase activity. The enzyme is involved in ascorbate biosynthesis. It catalyzes the conversion of GDP-D-mannose to GDP-L-galactose.
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    Genomic context

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    See GME in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (10862016..10864946, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene calcium-binding EF hand family protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Calcium-binding EF-hand family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GDP-mannose 3',5'-epimerase forms GDP-L-gulose, a putative intermediate for the de novo biosynthesis of vitamin C in plants. Wolucka BA, et al. J Biol Chem, 2003 Nov 28. PMID 12954627
    2. Partial purification and identification of GDP-mannose 3",5"-epimerase of Arabidopsis thaliana, a key enzyme of the plant vitamin C pathway. Wolucka BA, et al. Proc Natl Acad Sci U S A, 2001 Dec 18. PMID 11752432, Free PMC Article
    3. Protein and metabolite composition of Arabidopsis stress granules. Kosmacz M, et al. New Phytol, 2019 May. PMID 30664249
    4. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203488.1
    NM_122767.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GDP-mannose 3,5-epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP-mannose 3,5-epimerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables NAD binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-ascorbic acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    GDP-D-mannose 3',5'-epimerase
    NP_001190417.1
    • ''GDP-D-mannose 3',5'-epimerase'' (GME); CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT3G62830.2).
    NP_198236.1
    • ''GDP-D-mannose 3',5'-epimerase'' (GME); FUNCTIONS IN: NAD or NADH binding, GDP-mannose 3,5-epimerase activity, catalytic activity; INVOLVED IN: L-ascorbic acid biosynthetic process, nucleotide-sugar metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT3G62830.2); Has 30173 Blast hits to 30172 proteins in 2803 species: Archae - 688; Bacteria - 17773; Metazoa - 351; Fungi - 177; Plants - 999; Viruses - 17; Other Eukaryotes - 10168 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      10862016..10864946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122767.4 → NP_198236.1  GDP-D-mannose 3',5'-epimerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198236.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93VR3
      UniProtKB/TrEMBL
      A0A178ULP4, A0A384LF84, Q0WWW3
      Conserved Domains (1) summary
      PLN02695
      Location:7 → 377
      PLN02695; GDP-D-mannose-3',5'-epimerase

    2. NM_001203488.1 → NP_001190417.1  GDP-D-mannose 3',5'-epimerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190417.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93VR3
      UniProtKB/TrEMBL
      A0A178ULP4, A0A384LF84, Q0WWW3
      Conserved Domains (1) summary
      PLN02695
      Location:7 → 377
      PLN02695; GDP-D-mannose-3',5'-epimerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93VR3.1

    Gene LinkOut

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