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    SQE6 squalene monooxygenase 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832482, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SQE6
    Official Full Name
    squalene monooxygenase 6
    Primary source
    TAIR:AT5G24160
    Locus tag
    AT5G24160
    See related
    Araport:AT5G24160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    K12G2.4; K12G2_4; squalene monoxygenase 6
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    Genomic context

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    See SQE6 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (8182917..8186704, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene FAD/NAD(P)-binding oxidoreductase family protein Neighboring gene FAD/NAD(P)-binding oxidoreductase family protein Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene Got1/Sft2-like vescicle transport protein family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An example of intron junctional sliding in the gene families encoding squalene monooxygenase homologues in Arabidopsis thaliana and Brassica napus. Schäfer UA, et al. Plant Mol Biol, 1999 Mar. PMID 10350086
    2. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_001343845.1
    NM_001343846.1
    NM_122321.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables squalene monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sterol biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    squalene monooxygenase 6
    NP_197804.1
    • squalene monoxygenase 6 (SQE6); FUNCTIONS IN: squalene monooxygenase activity, oxidoreductase activity, FAD binding; INVOLVED IN: sterol biosynthetic process; LOCATED IN: endomembrane system, integral to membrane; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: Squalene epoxidase (InterPro:IPR013698), FAD dependent oxidoreductase (InterPro:IPR006076); BEST Arabidopsis thaliana protein match is: FAD/NAD(P)-binding oxidoreductase family protein (TAIR:AT5G24150.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      8182917..8186704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122321.5 → NP_197804.1  squalene monooxygenase 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197804.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65402
      UniProtKB/TrEMBL
      A0A178UL03
      Conserved Domains (3) summary
      PLN02985
      Location:3 → 517
      PLN02985; squalene monooxygenase
      pfam13450
      Location:50 → 77
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:199 → 473
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001343845.1 → NP_001330191.1  squalene monooxygenase 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BA09

    3. NM_001343846.1 → NP_001330190.1  squalene monooxygenase 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BA10, A0A5S9Y938, A0A654G466
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O65402.1

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