IMS2 2-isopropylmalate synthase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: IMS2
Official Full Name: 2-isopropylmalate synthase 2
Primary source: TAIR:AT5G23020
Locus tag: AT5G23020
See related: Araport:AT5G23020
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 2-isopropylmalate synthase 2; MAM-L; MAM3; METHYLTHIOALKYMALATE SYNTHASE-LIKE; MYJ24.1; MYJ24_1
Summary: methylthioalkymalate synthase-like. Also known as 2-isopropylmalate synthase (IMS2). encodes a methylthioalkylmalate synthase involved in the biosynthesis of aliphatic glucosinolates which accepts all the omega-methylthio-2-oxoalkanoic acids needed to form the known C3 to C8 glucosinolates in Arabidopsis.
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Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

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Changing substrate specificity and iteration of amino acid chain elongation in glucosinolate biosynthesis through targeted mutagenesis of Arabidopsis methylthioalkylmalate synthase 1.
Title: Changing substrate specificity and iteration of amino acid chain elongation in glucosinolate biosynthesis through targeted mutagenesis of Arabidopsis methylthioalkylmalate synthase 1.
We studied the expression patterns of MAM1 and MAM3 genes in different organs and developmental stages using promoter-GUS fusion lines and qRT-PCR.
Title: Expression pattern of the glucosinolate side chain biosynthetic genes MAM1 and MAM3 of Arabidopsis thaliana in different organs and developmental stages.
MAM3 (formerly known as MAM-L)catalyzes the formation of all glucosinolate chain lengths in vivo as well as in vitro.
Title: MAM3 catalyzes the formation of all aliphatic glucosinolate chain lengths in Arabidopsis.

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NM_122208.4

Function	Evidence Code	Pubs
NOT enables 2-isopropylmalate synthase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables 2-isopropylmalate synthase activity	NAS Non-traceable Author Statement more info	PubMed
enables methylthioalkylmalate synthase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within L-leucine biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within glucosinolate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glucosinolate biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within glucosinolate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info

NP_197693.1

2-isopropylmalate synthase 2 (IMS2); CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Alpha-isopropylmalate/homocitrate synthase, conserved site (InterPro:IPR002034), Pyruvate carboxyltransferase (InterPro:IPR000891); BEST Arabidopsis thaliana protein match is: methylthioalkylmalate synthase 1 (TAIR:AT5G23010.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

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