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    RAN2 RAS-related GTP-binding nuclear protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832124, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RAN2
    Official Full Name
    RAS-related GTP-binding nuclear protein 2
    Primary source
    TAIR:AT5G20020
    Locus tag
    AT5G20020
    See related
    Araport:AT5G20020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F28I16.170; F28I16_170; RAS-related GTP-binding nuclear protein 2
    Summary
    A member of RAN GTPase gene family. Encodes a small soluble GTP-binding protein. Likely to be involved in nuclear translocation of proteins. May also be involved in cell cycle progression.
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    Genomic context

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    See RAN2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (6762569..6764683)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene AAA-type ATPase family protein Neighboring gene RAS-related nuclear protein-1 Neighboring gene Plant Tudor-like RNA-binding protein Neighboring gene isopentenyltransferase 9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Perinuclear and nuclear envelope localizations of Arabidopsis Ran proteins. Ma L, et al. Plant Cell Rep, 2007 Aug. PMID 17530257
    2. A novel RNA-binding protein associated with cell plate formation. Ma L, et al. Plant Physiol, 2008 Sep. PMID 18621982, Free PMC Article
    3. Characterization of proteins that interact with the GTP-bound form of the regulatory GTPase Ran in Arabidopsis. Haizel T, et al. Plant J, 1997 Jan. PMID 9025305
    4. An Arabidopsis homolog of importin β1 is required for ABA response and drought tolerance. Luo Y, et al. Plant J, 2013 Aug. PMID 23582042
    5. The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes. Shibano T, et al. PLoS One, 2015. PMID 25946333, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ran2 mRNA binds to phragmoplastin-interacting protein.
      Title: A novel RNA-binding protein associated with cell plate formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_122009.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein import into nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in cytoplasm HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in intracellular anatomical structure TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    RAS-related GTP-binding nuclear protein 2
    NP_197502.1
    • RAS-related GTP-binding nuclear protein 2 (RAN2); FUNCTIONS IN: protein binding, GTP binding, GTPase activity; INVOLVED IN: response to cadmium ion, protein import into nucleus; LOCATED IN: nucleolus, nucleus, cytoplasm; EXPRESSED IN: cotyledon, guard cell, cultured cell; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Ran GTPase (InterPro:IPR002041), Small GTP-binding protein (InterPro:IPR005225), Ras (InterPro:IPR013753); BEST Arabidopsis thaliana protein match is: RAN GTPase 3 (TAIR:AT5G55190.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      6762569..6764683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122009.4 → NP_197502.1  RAS-related GTP-binding nuclear protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197502.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41917, Q0WVD9, Q94K33
      UniProtKB/TrEMBL
      A0A178UQ77, A0A5S9Y5R9, A0A5S9Y6M6
      Conserved Domains (1) summary
      PLN03071
      Location:1 → 219
      PLN03071; GTP-binding nuclear protein Ran; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41917.3

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