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    PAS2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830912, updated on 22-Aug-2024

    Summary

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    Official Symbol
    PAS2
    Primary source
    Araport:AT5G10480
    Locus tag
    AT5G10480
    See related
    TAIR:AT5G10480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F12B17.170; F12B17_170; PASTICCINO 2; PEP; PEPINO
    Summary
    Protein tyrosine phosphatase-like involved in cell division and differentiation. Interacts with CDKA;1 only in its phosphorylated form, preventing dephosphorylation. Overexpression slowed down cell division in suspension cell cultures at the G2-to-M transition and early mitosis and inhibited Arabidopsis seedling growth. Localized in the cytoplasm of dividing cells but moved into the nucleus upon cell differentiation. Based on complementation of yeast mutant PAS2 has acyl-CoA dehydratase activity. It interacts with CER10, a component of the microsomal fatty acid elongase complex, suggesting a role in synthesis of VLCFAs (very long chain fatty acids).
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (3297804..3300165, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene Haloacid dehalogenase-like hydrolase (HAD) superfamily protein Neighboring gene kinesin like protein for actin based chloroplast movement 1 Neighboring gene MSCS-like 2 Neighboring gene Kinase interacting (KIP1-like) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Sos-recruitment system as a tool to analyze cellular localization of plant proteins: membrane localization of Arabidopsis thaliana PEPINO/PASTICCINO2. Schönhofer-Merl S, et al. Mol Genet Genomics, 2010 May. PMID 20300944
    2. The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development. Bach L, et al. Proc Natl Acad Sci U S A, 2008 Sep 23. PMID 18799749, Free PMC Article
    3. Pasticcino2 is a protein tyrosine phosphatase-like involved in cell proliferation and differentiation in Arabidopsis. Bellec Y, et al. Plant J, 2002 Dec. PMID 12472687
    4. The PASTICCINO genes of Arabidopsis thaliana are involved in the control of cell division and differentiation. Faure JD, et al. Development, 1998 Mar. PMID 9449673
    5. Arabidopsis PASTICCINO2 is an antiphosphatase involved in regulation of cyclin-dependent kinase A. Da Costa M, et al. Plant Cell, 2006 Jun. PMID 16698944, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PEP/PAS2 is an integral membrane protein with cytosolic N- and C-termini.
      Title: The Sos-recruitment system as a tool to analyze cellular localization of plant proteins: membrane localization of Arabidopsis thaliana PEPINO/PASTICCINO2.
    2. 3-hydroxy-acyl-CoA dehydratase PASTICCINO2 is an essential and limiting enzyme in VLCFA synthesis but also that PAS2-derived VLCFA homeostasis is required for specific developmental processes
      Title: The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development.
    3. The balance between cell division and differentiation is regulated through the interaction between CDKA;1 and the antiphosphatase PAS2.
      Title: Arabidopsis PASTICCINO2 is an antiphosphatase involved in regulation of cyclin-dependent kinase A.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001085097.1
    NM_001203348.1
    NM_121086.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydratase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within very long-chain fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    part_of fatty acid elongase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein-tyrosine phosphatase-like, PTPLA
    NP_001078566.1
    • PASTICCINO 2 (PAS2); FUNCTIONS IN: protein tyrosine phosphatase activity, enoyl-CoA hydratase activity; INVOLVED IN: cell differentiation, negative regulation of peptidyl-tyrosine phosphorylation, regulation of cell division, negative regulation of developmental growth; LOCATED IN: cytosol, integral to membrane, nucleus, fatty acid elongase complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase-like, PTPLA (InterPro:IPR007482); BEST Arabidopsis thaliana protein match is: Protein-tyrosine phosphatase-like, PTPLA (TAIR:AT5G59770.1); Has 727 Blast hits to 727 proteins in 205 species: Archae - 0; Bacteria - 0; Metazoa - 341; Fungi - 179; Plants - 124; Viruses - 0; Other Eukaryotes - 83 (source: NCBI BLink).
    NP_001190277.1
    • PASTICCINO 2 (PAS2); CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase-like, PTPLA (InterPro:IPR007482); BEST Arabidopsis thaliana protein match is: Protein-tyrosine phosphatase-like, PTPLA (TAIR:AT5G59770.1).
    NP_196610.2
    • PASTICCINO 2 (PAS2); CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase-like, PTPLA (InterPro:IPR007482); BEST Arabidopsis thaliana protein match is: Protein-tyrosine phosphatase-like, PTPLA (TAIR:AT5G59770.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      3297804..3300165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121086.5 → NP_196610.2  Protein-tyrosine phosphatase-like, PTPLA [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196610.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MQH5, Q8VZB2, Q9LXA0
      UniProtKB/TrEMBL
      A0A654FZY2
      Conserved Domains (1) summary
      PLN02838
      Location:1 → 221
      PLN02838; 3-hydroxyacyl-CoA dehydratase subunit of elongase

    2. NM_001085097.1 → NP_001078566.1  Protein-tyrosine phosphatase-like, PTPLA [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078566.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y304
      Conserved Domains (1) summary
      PLN02838
      Location:1 → 196
      PLN02838; 3-hydroxyacyl-CoA dehydratase subunit of elongase

    3. NM_001203348.1 → NP_001190277.1  Protein-tyrosine phosphatase-like, PTPLA [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190277.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FZY2, F4KGW0
      Conserved Domains (1) summary
      PLN02838
      Location:1 → 230
      PLN02838; 3-hydroxyacyl-CoA dehydratase subunit of elongase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VZB2.1

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