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    PAI2 phosphoribosylanthranilate isomerase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830442, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PAI2
    Official Full Name
    phosphoribosylanthranilate isomerase 2
    Primary source
    TAIR:AT5G05590
    Locus tag
    AT5G05590
    See related
    Araport:AT5G05590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MOP10.13; MOP10_13; PHOSPHORIBOSYLANTHRANILATE ISOMERASE; phosphoribosylanthranilate isomerase 2
    Summary
    Encodes phosphoribosylanthranilate isomerase which catalyzes the third step in the tryptophan biosynthetic pathway.
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    Genomic context

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    See PAI2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (1666471..1668569, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene sequence-specific DNA binding transcription factor Neighboring gene E3 ubiquitin ligase Neighboring gene transducin family protein / WD-40 repeat family protein Neighboring gene fatty acid desaturase 8 Neighboring gene uncharacterized protein Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis phosphoribosylanthranilate isomerase: molecular genetic analysis of triplicate tryptophan pathway genes. Li J, et al. Plant Cell, 1995 Apr. PMID 7773017, Free PMC Article
    2. Immunological characterization and chloroplast localization of the tryptophan biosynthetic enzymes of the flowering plant Arabidopsis thaliana. Zhao J, et al. J Biol Chem, 1995 Mar 17. PMID 7890741
    3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    NM_001342827.1
    NM_001342828.1
    NM_120641.5
    NM_203005.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphoribosylanthranilate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylanthranilate isomerase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables phosphoribosylanthranilate isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tryptophan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tryptophan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tryptophan biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphoribosylanthranilate isomerase 2
    NP_196178.2
    • phosphoribosylanthranilate isomerase 2 (PAI2); CONTAINS InterPro DOMAIN/s: N-(5'phosphoribosyl)anthranilate isomerase (PRAI) (InterPro:IPR001240), Aldolase-type TIM barrel (InterPro:IPR013785), Ribulose-phosphate binding barrel (InterPro:IPR011060); BEST Arabidopsis thaliana protein match is: phosphoribosylanthranilate isomerase 1 (TAIR:AT1G07780.5); Has 5501 Blast hits to 5500 proteins in 2129 species: Archae - 169; Bacteria - 3874; Metazoa - 4; Fungi - 235; Plants - 77; Viruses - 0; Other Eukaryotes - 1142 (source: NCBI BLink).
    NP_974734.1
    • phosphoribosylanthranilate isomerase 2 (PAI2); CONTAINS InterPro DOMAIN/s: N-(5'phosphoribosyl)anthranilate isomerase (PRAI) (InterPro:IPR001240), Aldolase-type TIM barrel (InterPro:IPR013785), Ribulose-phosphate binding barrel (InterPro:IPR011060); BEST Arabidopsis thaliana protein match is: phosphoribosylanthranilate isomerase 1 (TAIR:AT1G07780.4); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      1666471..1668569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120641.5 → NP_196178.2  phosphoribosylanthranilate isomerase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196178.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4K0R4, Q42527, Q9FFF7
      UniProtKB/TrEMBL
      A0A5S9Y1Y1, A0A7G2F7D8
      Conserved Domains (2) summary
      PLN02363
      Location:19 → 275
      PLN02363; phosphoribosylanthranilate isomerase
      cd00405
      Location:68 → 270
      PRAI; Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric, ...

    2. NM_203005.2 → NP_974734.1  phosphoribosylanthranilate isomerase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974734.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42527
      Conserved Domains (2) summary
      PLN02363
      Location:19 → 242
      PLN02363; phosphoribosylanthranilate isomerase
      cd00405
      Location:68 → 232
      PRAI; Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric, ...

    3. NM_001342827.1 → NP_001330071.1  phosphoribosylanthranilate isomerase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B9M1

    4. NM_001342828.1 → NP_001330072.1  phosphoribosylanthranilate isomerase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B9P1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42527.1

    Gene LinkOut

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