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    CGL1 alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829981, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CGL1
    Official Full Name
    alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
    Primary source
    TAIR:AT4G38240
    Locus tag
    AT4G38240
    See related
    Araport:AT4G38240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CGL; COMPLEX GLYCAN LESS; COMPLEX GLYCAN LESS 1; F20D10.360; F20D10_360; GNTI; N-ACETYLGLUCOSAMINYLTRANSFERASE I
    Summary
    Encodes N-acetyl glucosaminyl transferase I, the first enzyme in the pathway of complex glycan biosynthesis.
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    Genomic context

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    See CGL1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    19
    Sequence:
    Chromosome: 4; NC_003075.7 (17931570..17935325, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Peptidase M20/M25/M40 family protein Neighboring gene glycerol kinase Neighboring gene calcium-dependent protein kinase 26 Neighboring gene Transmembrane amino acid transporter family protein Neighboring gene ncRNA Neighboring gene transport/golgi organization-like protein (DUF833) Neighboring gene galacturonosyltransferase 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Golgi Localization of GnTI Requires a Polar Amino Acid Residue within Its Transmembrane Domain. Schoberer J, et al. Plant Physiol, 2019 Jun. PMID 30971450, Free PMC Article
    2. Comparative analyses of Arabidopsis complex glycan1 mutants and genetic interaction with staurosporin and temperature sensitive3a. Frank J, et al. Plant Physiol, 2008 Nov. PMID 18768906, Free PMC Article
    3. Molecular basis of N-acetylglucosaminyltransferase I deficiency in Arabidopsis thaliana plants lacking complex N-glycans. Strasser R, et al. Biochem J, 2005 Apr 15. PMID 15537386, Free PMC Article
    4. An Arabidopsis thaliana cDNA complements the N-acetylglucosaminyltransferase I deficiency of CHO Lec1 cells. Bakker H, et al. Biochem Biophys Res Commun, 1999 Aug 11. PMID 10441510
    5. Isolation of a mutant Arabidopsis plant that lacks N-acetyl glucosaminyl transferase I and is unable to synthesize Golgi-modified complex N-linked glycans. von Schaewen A, et al. Plant Physiol, 1993 Aug. PMID 8278542, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001204022.1
    NM_119986.3
    NM_179186.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein N-acetylglucosaminyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within N-glycan processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in Golgi apparatus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in Golgi medial cisterna HDA PubMed 
    located_in endosome HDA PubMed 
    located_in trans-Golgi network HDA PubMed 

    General protein information

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    Preferred Names
    alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
    NP_001190951.1
    • COMPLEX GLYCAN LESS 1 (CGL1); CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 13 (InterPro:IPR004139).
    NP_195537.2
    • COMPLEX GLYCAN LESS 1 (CGL1); CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 13 (InterPro:IPR004139); Has 453 Blast hits to 453 proteins in 90 species: Archae - 0; Bacteria - 4; Metazoa - 330; Fungi - 0; Plants - 71; Viruses - 0; Other Eukaryotes - 48 (source: NCBI BLink).
    NP_849517.1
    • COMPLEX GLYCAN LESS 1 (CGL1); CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 13 (InterPro:IPR004139); Has 453 Blast hits to 453 proteins in 90 species: Archae - 0; Bacteria - 4; Metazoa - 330; Fungi - 0; Plants - 71; Viruses - 0; Other Eukaryotes - 48 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17931570..17935325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119986.3 → NP_195537.2  alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195537.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VWR5, Q9SVG1, Q9SZM4, Q9XGM8
      UniProtKB/TrEMBL
      A0A178UU47, W8Q2W3
      Conserved Domains (2) summary
      pfam03071
      Location:13 → 443
      GNT-I; GNT-I family
      pfam13641
      Location:107 → 310
      Glyco_tranf_2_3; Glycosyltransferase like family 2

    2. NM_179186.1 → NP_849517.1  alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849517.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VWR5, Q9SVG1, Q9SZM4, Q9XGM8
      UniProtKB/TrEMBL
      A0A178UU47, W8Q2W3
      Conserved Domains (2) summary
      pfam03071
      Location:13 → 443
      GNT-I; GNT-I family
      pfam13641
      Location:107 → 310
      Glyco_tranf_2_3; Glycosyltransferase like family 2

    3. NM_001204022.1 → NP_001190951.1  alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190951.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FWP6, A0A7G2F5N7, F4JTL6
      Conserved Domains (1) summary
      pfam03071
      Location:13 → 432
      GNT-I; GNT-I family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XGM8.1

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