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    PEN1 pentacyclic triterpene synthase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827200, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PEN1
    Official Full Name
    pentacyclic triterpene synthase 1
    Primary source
    TAIR:AT4G15340
    Locus tag
    AT4G15340
    See related
    Araport:AT4G15340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    04C11; ATPEN1; DL3715C; FCAALL.158; PENTACYCLIC TRITERPENE SYNTHASE; pentacyclic triterpene synthase 1
    Summary
    Encodes a protein that catalyzes the production of the tricyclic triterpene arabidiol when expressed in yeast.
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    Genomic context

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    See PEN1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    14
    Sequence:
    Chromosome: 4; NC_003075.7 (8754440..8760600, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene cytochrome P450, family 705, subfamily A, polypeptide 1 Neighboring gene miscRNA Neighboring gene cytochrome P450, family 705, subfamily A, polypeptide 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stereochemistry of water addition in triterpene synthesis: the structure of arabidiol. Kolesnikova MD, et al. Org Lett, 2007 May 24. PMID 17474751
    2. A new triterpene synthase from Arabidopsis thaliana produces a tricyclic triterpene with two hydroxyl groups. Xiang T, et al. Org Lett, 2006 Jun 22. PMID 16774269
    3. Arabidopsis ARF-GTP exchange factor, GNOM, mediates transport required for innate immunity and focal accumulation of syntaxin PEN1. Nielsen ME, et al. Proc Natl Acad Sci U S A, 2012 Jul 10. PMID 22733775, Free PMC Article
    4. Pre- and postinvasion defenses both contribute to nonhost resistance in Arabidopsis. Lipka V, et al. Science, 2005 Nov 18. PMID 16293760
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis ARF-GTP exchange factor, GNOM, mediates transport required for innate immunity and focal accumulation of syntaxin PEN1
      Title: Arabidopsis ARF-GTP exchange factor, GNOM, mediates transport required for innate immunity and focal accumulation of syntaxin PEN1.
    2. the importance of PEN1 and PEN2 functions in powdery mildew nonhost interaction
      Title: Pre- and postinvasion defenses both contribute to nonhost resistance in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001341033.1
    NM_117622.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables arabidiol synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within tricyclic triterpenoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within triterpenoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in triterpenoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in triterpenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    pentacyclic triterpene synthase 1
    NP_567462.1
    • pentacyclic triterpene synthase 1 (PEN1); CONTAINS InterPro DOMAIN/s: Terpene synthase, conserved site (InterPro:IPR002365), Terpenoid cylases/protein prenyltransferase alpha-alpha toroid (InterPro:IPR008930), Squalene cyclase (InterPro:IPR018333), Prenyltransferase/squalene oxidase (InterPro:IPR001330); BEST Arabidopsis thaliana protein match is: baruol synthase 1 (TAIR:AT4G15370.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      8754440..8760600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117622.3 → NP_567462.1  pentacyclic triterpene synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567462.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23388, Q08J21, Q9FR95
      UniProtKB/TrEMBL
      A0A5S9XSL3, A0A654FPN2
      Conserved Domains (1) summary
      PLN03012
      Location:1 → 757
      PLN03012; Camelliol C synthase

    2. NM_001341033.1 → NP_001328610.1  pentacyclic triterpene synthase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B580
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FR95.1

    Gene LinkOut

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