RHF1A RING-H2 group F1A [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: RHF1A
Official Full Name: RING-H2 group F1A
Primary source: TAIR:AT4G14220
Locus tag: AT4G14220
See related: Araport:AT4G14220
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: DL3150W; FCAALL.146; RING-H2 group F1A
Summary: encodes a RING-type E3 ubiquitin ligase implicated in gametogenesis. RHF1a can interact with the cell cycle inhibitor ICK4/KRP6 in vitro. It apppears to target ICK4KRP6 for degradation following meiosis in order to allow the mitoses associated with megagametogenesis and microgametogenesis to occur. RHF1a is expressed in the carpels throughout floral development. It is expressed in various tissues of the anthers during the early stages of anther development but not in stage 12 flowers and beyond.
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Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_117499.5

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within megagametogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within microgametogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within proteasomal protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell cycle	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

NP_193158.2

RING-H2 group F1A (RHF1A); FUNCTIONS IN: ubiquitin-protein ligase activity, zinc ion binding; INVOLVED IN: regulation of cell cycle, proteasomal protein catabolic process, megagametogenesis, microgametogenesis; LOCATED IN: membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING-H2 group F2A (TAIR:AT5G22000.3); Has 5179 Blast hits to 4938 proteins in 253 species: Archae - 0; Bacteria - 16; Metazoa - 1752; Fungi - 320; Plants - 2058; Viruses - 9; Other Eukaryotes - 1024 (source: NCBI BLink).