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    HRS1 Histidyl-tRNA synthetase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823753, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HRS1
    Official Full Name
    Histidyl-tRNA synthetase 1
    Primary source
    TAIR:AT3G46100
    Locus tag
    AT3G46100
    See related
    Araport:AT3G46100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATHRS1; HISTIDYL-TRNA SYNTHETASE; Histidyl-tRNA synthetase 1
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    Genomic context

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    See HRS1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Sequence:
    Chromosome: 3; NC_003074.8 (16928158..16931053, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene C2H2 and C2HC zinc fingers superfamily protein Neighboring gene UPSTREAM OF FLC-like protein (DUF966) Neighboring gene purple acid phosphatase 19

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Potential dual targeting of an Arabidopsis archaebacterial-like histidyl-tRNA synthetase to mitochondria and chloroplasts. Akashi K, et al. FEBS Lett, 1998 Jul 10. PMID 9684861
    2. Dual targeting is the rule for organellar aminoacyl-tRNA synthetases in Arabidopsis thaliana. Duchêne AM, et al. Proc Natl Acad Sci U S A, 2005 Nov 8. PMID 16251277, Free PMC Article
    3. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713
    5. Multi-omics network-based functional annotation of unknown Arabidopsis genes. Depuydt T, et al. Plant J, 2021 Nov. PMID 34562334

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_114479.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histidine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within histidyl-tRNA aminoacylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Histidyl-tRNA synthetase 1
    NP_190196.1
    • Histidyl-tRNA synthetase 1 (HRS1); FUNCTIONS IN: histidine-tRNA ligase activity; INVOLVED IN: histidyl-tRNA aminoacylation; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Histidyl-tRNA synthetase, class IIa, subgroup (InterPro:IPR015807), Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain (InterPro:IPR002314), Anticodon-binding (InterPro:IPR004154), Aminoacyl-tRNA synthetase, class II, conserved domain (InterPro:IPR006195), Histidyl-tRNA synthetase, class IIa (InterPro:IPR004516); BEST Arabidopsis thaliana protein match is: Class II aaRS and biotin synthetases superfamily protein (TAIR:AT5G03406.1); Has 12183 Blast hits to 12140 proteins in 2982 species: Archae - 258; Bacteria - 7725; Metazoa - 293; Fungi - 147; Plants - 90; Viruses - 0; Other Eukaryotes - 3670 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      16928158..16931053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114479.5 → NP_190196.1  Histidyl-tRNA synthetase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190196.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82413
      UniProtKB/TrEMBL
      A0A178VI84, A0A5S9XID2, A0A654FE54
      Conserved Domains (1) summary
      PLN02530
      Location:2 → 486
      PLN02530; histidine-tRNA ligase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82413.1

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