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    SKOR STELAR K+ outward rectifier [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821052, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SKOR
    Official Full Name
    STELAR K+ outward rectifier
    Primary source
    TAIR:AT3G02850
    Locus tag
    AT3G02850
    See related
    Araport:AT3G02850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F13E7.21; F13E7_21; STELAR K+ outward rectifier
    Summary
    Encodes SKOR, a member of Shaker family potassium ion (K+) channel. This family includes five groups based on phylogenetic analysis (FEBS Letters (2007) 581: 2357): I (inward rectifying channel): AKT1 (AT2G26650), AKT5 (AT4G32500) and SPIK (also known as AKT6, AT2G25600); II (inward rectifying channel): KAT1 (AT5G46240) and KAT2 (AT4G18290); III (weakly inward rectifying channel): AKT2 (AT4G22200); IV (regulatory subunit involved in inwardly rectifying conductance formation): KAT3 (also known as AtKC1, AT4G32650); V (outward rectifying channel): SKOR (AT3G02850) and GORK (AT5G37500). Mediates the delivery of K+ from stelar cells to the xylem in the roots towards the shoot. mRNA accumulation is modulated by abscisic acid. K+ gating activity is modulated by external and internal K+.
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    Genomic context

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    See SKOR in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Sequence:
    Chromosome: 3; NC_003074.8 (619678..623739, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ARM repeat superfamily protein Neighboring gene ncRNA Neighboring gene zinc ion binding protein Neighboring gene Inositol monophosphatase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A minimal cysteine motif required to activate the SKOR K+ channel of Arabidopsis by the reactive oxygen species H2O2. Garcia-Mata C, et al. J Biol Chem, 2010 Sep 17. PMID 20605786, Free PMC Article
    2. Single mutations convert an outward K+ channel into an inward K+ channel. Li L, et al. Proc Natl Acad Sci U S A, 2008 Feb 26. PMID 18287042, Free PMC Article
    3. External K+ modulates the activity of the Arabidopsis potassium channel SKOR via an unusual mechanism. Johansson I, et al. Plant J, 2006 Apr. PMID 16623889
    4. Intracellular K+ sensing of SKOR, a Shaker-type K+ channel from Arabidopsis. Liu K, et al. Plant J, 2006 Apr. PMID 16623888
    5. Identification and disruption of a plant shaker-like outward channel involved in K+ release into the xylem sap. Gaymard F, et al. Cell, 1998 Sep 4. PMID 9741629

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that nutritional conditions as a critical factor for the joint activity of Arabidopsis proteins SKOR and NPF7.3/NRT1.5 for shoot potassium (K) homeostasis.
      Title: Nitrate-Dependent Control of Shoot K Homeostasis by the Nitrate Transporter1/Peptide Transporter Family Member NPF7.3/NRT1.5 and the Stelar K+ Outward Rectifier SKOR in Arabidopsis.
    2. Study found that, in particular, the N-terminal part of the S5 played a critical role in KAT1 and SKOR gating.
      Title: Distributed structures underlie gating differences between the kin channel KAT1 and the Kout channel SKOR.
    3. A minimal cysteine motif required to activate the SKOR K+ channel of Arabidopsis by the reactive oxygen species H2O2.
      Title: A minimal cysteine motif required to activate the SKOR K+ channel of Arabidopsis by the reactive oxygen species H2O2.
    4. Single mutations in SKOR convert it from an outward K+ channel into an inward K+ channel.
      Title: Single mutations convert an outward K+ channel into an inward K+ channel.
    5. Mapping the SKOR sequence to the crystal structure of the voltage-dependent K+ channel suggests interaction between the S6 gating domain and the base of the pore helix, a prediction supported by mutations at this site.
      Title: External K+ modulates the activity of the Arabidopsis potassium channel SKOR via an unusual mechanism.
    6. The intracellular potassium sensing mechanism couples SKOR activity to potassium nutrition status in the 'source cells', establishing a supply-based unloading system for the regulation of potassium distribution.
      Title: Intracellular K+ sensing of SKOR, a Shaker-type K+ channel from Arabidopsis.
    7. Phosphatidylinositol phosphates were identified as essential regulators for the voltage-dependent and -independent activation of A. thaliana potassium channels expressed in X. laevis oocytes.
      Title: An essential function of phosphatidylinositol phosphates in activation of plant shaker-type K+ channels.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001337437.1
    NM_001337438.1
    NM_111153.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables inward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables outward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within potassium ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    STELAR K+ outward rectifier
    NP_186934.1
    • STELAR K+ outward rectifier (SKOR); FUNCTIONS IN: outward rectifier potassium channel activity, cyclic nucleotide binding; INVOLVED IN: potassium ion transport, response to abscisic acid stimulus; LOCATED IN: membrane; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis; CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Potassium channel, voltage-dependent, EAG/ELK/ERG (InterPro:IPR003938), Protein of unknown function DUF3354 (InterPro:IPR021789), Ankyrin repeat-containing domain (InterPro:IPR020683), Ion transport (InterPro:IPR005821), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: gated outwardly-rectifying K+ channel (TAIR:AT5G37500.1); Has 82938 Blast hits to 34972 proteins in 1815 species: Archae - 147; Bacteria - 10317; Metazoa - 39460; Fungi - 7131; Plants - 3765; Viruses - 1138; Other Eukaryotes - 20980 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      619678..623739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111153.4 → NP_186934.1  STELAR K+ outward rectifier [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_186934.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82630, Q9M8S6, Q9SB86
      UniProtKB/TrEMBL
      A0A178VHK5, A0A5S9X8K2
      Conserved Domains (2) summary
      PLN03192
      Location:70 → 827
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:580 → 611
      ANK; ANK repeat [structural motif]

    2. NM_001337437.1 → NP_001325630.1  STELAR K+ outward rectifier [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LLU1

    3. NM_001337438.1 → NP_001325629.1  STELAR K+ outward rectifier [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LLU0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M8S6.1

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