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    ADT2 arogenate dehydratase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819954, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ADT2
    Official Full Name
    arogenate dehydratase 2
    Primary source
    TAIR:AT3G07630
    Locus tag
    AT3G07630
    See related
    Araport:AT3G07630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana arogenate dehydratase 2; arogenate dehydratase 2; AtADT2
    Summary
    Encodes a plastid-localized arogenate dehydratase involved in phenylalanine biosynthesis. Not less than six genes encoding ADT were identified in the Arabidopsis genome: ADT1 [At1g11790]; ADT2 [At3g07630]; ADT3 [At2g27820]; ADT4 [At3g44720]; ADT5 [At5g22630]; and ADT6 [At1g08250].
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    Genomic context

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    See ADT2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Sequence:
    Chromosome: 3; NC_003074.8 (2435408..2437989)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Transcription factor jumonji (jmjC) domain-containing protein Neighboring gene glycosyltransferase Neighboring gene period circadian protein Neighboring gene CONSTANS-like 9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Family Members and Their Individual Roles: An Arabidopsis Arogenate Dehydratase ADT2 and its Role in Seed Development. Xu Z, et al. Plant Cell Physiol, 2018 Dec 1. PMID 30462311
    2. The Arogenate Dehydratase ADT2 is Essential for Seed Development in Arabidopsis. El-Azaz J, et al. Plant Cell Physiol, 2018 Dec 1. PMID 30289532
    3. Moonlighting proteins: putting the spotlight on enzymes. Abolhassani Rad S, et al. Plant Signal Behav, 2018. PMID 30252596, Free PMC Article
    4. Pleiotropic physiological consequences of feedback-insensitive phenylalanine biosynthesis in Arabidopsis thaliana. Huang T, et al. Plant J, 2010 Sep. PMID 20598094
    5. Complementation of the pha2 yeast mutant suggests functional differences for arogenate dehydratases from Arabidopsis thaliana. Bross CD, et al. Plant Physiol Biochem, 2011 Aug. PMID 21388819

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. role in seed development
      Title: Family Members and Their Individual Roles: An Arabidopsis Arogenate Dehydratase ADT2 and its Role in Seed Development.
    2. a deficiency in ADT2, a bifunctional arogenate dehydratase (ADT)/prephenate dehydratase (PDT) enzyme, causes embryo arrest and seed abortion.
      Title: The Arogenate Dehydratase ADT2 is Essential for Seed Development in Arabidopsis.
    3. ADT2 can use prephenate as a substrate and can function as a prephenate dehydratase
      Title: Complementation of the pha2 yeast mutant suggests functional differences for arogenate dehydratases from Arabidopsis thaliana.
    4. Data show that rlaxed feedback inhibition and increased expression of the ADT2 mutant enzyme caused up to 160-fold higher accumulation of free phenylalanine in rosette leaves, as well as altered accumulation of several other metabolites.
      Title: Pleiotropic physiological consequences of feedback-insensitive phenylalanine biosynthesis in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001337726.1
    NM_111642.3
    NM_202520.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables arogenate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables prephenate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-phenylalanine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloroplast fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in stromule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arogenate dehydratase 2
    NP_187420.1
    • arogenate dehydratase 2 (ADT2); FUNCTIONS IN: arogenate dehydratase activity, prephenate dehydratase activity; INVOLVED IN: L-phenylalanine biosynthetic process, metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Prephenate dehydratase (InterPro:IPR001086), Amino acid-binding ACT (InterPro:IPR002912), Prephenate dehydratase, conserved site (InterPro:IPR018528); BEST Arabidopsis thaliana protein match is: arogenate dehydratase 1 (TAIR:AT1G11790.1); Has 7238 Blast hits to 7235 proteins in 2227 species: Archae - 179; Bacteria - 3971; Metazoa - 12; Fungi - 120; Plants - 262; Viruses - 0; Other Eukaryotes - 2694 (source: NCBI BLink).
    NP_974249.1
    • arogenate dehydratase 2 (ADT2); FUNCTIONS IN: arogenate dehydratase activity, prephenate dehydratase activity; INVOLVED IN: L-phenylalanine biosynthetic process, metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Prephenate dehydratase (InterPro:IPR001086), Amino acid-binding ACT (InterPro:IPR002912), Prephenate dehydratase, conserved site (InterPro:IPR018528); BEST Arabidopsis thaliana protein match is: arogenate dehydratase 1 (TAIR:AT1G11790.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2435408..2437989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111642.3 → NP_187420.1  arogenate dehydratase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187420.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LFI1, Q9SSE7
      UniProtKB/TrEMBL
      A0A5S9XA20, A0A654F554
      Conserved Domains (3) summary
      cd04905
      Location:287 → 375
      ACT_CM-PDT; C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme
      PLN02317
      Location:7 → 381
      PLN02317; arogenate dehydratase
      cd13631
      Location:98 → 277
      PBP2_Ct-PDT_like; Catalytic domain of prephenate dehydratase from Chlorobium tepidum and similar proteins, subgroup 2; the type 2 periplasmic binding protein fold

    2. NM_001337726.1 → NP_001325505.1  arogenate dehydratase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LFI1, Q9SSE7
      UniProtKB/TrEMBL
      A0A5S9XA20, A0A654F554

    3. NM_202520.2 → NP_974249.1  arogenate dehydratase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974249.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LFI1, Q9SSE7
      UniProtKB/TrEMBL
      A0A5S9XA20, A0A654F554
      Conserved Domains (3) summary
      cd04905
      Location:287 → 375
      ACT_CM-PDT; C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme
      PLN02317
      Location:7 → 381
      PLN02317; arogenate dehydratase
      cd13631
      Location:98 → 277
      PBP2_Ct-PDT_like; Catalytic domain of prephenate dehydratase from Chlorobium tepidum and similar proteins, subgroup 2; the type 2 periplasmic binding protein fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SSE7.1

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