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    KIS tubulin folding cofactor A (KIESEL) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817592, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KIS
    Official Full Name
    tubulin folding cofactor A (KIESEL)
    Primary source
    TAIR:AT2G30410
    Locus tag
    AT2G30410
    See related
    Araport:AT2G30410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    KIESEL; T9D9.22; T9D9_22; TFCA; TUBULIN FOLDING FACTOR A
    Summary
    mutant has embryo defect; enlarged embryo cells and endosperm nuclei; Tubulin Folding Cofactor A
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    Genomic context

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    See KIS in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (12958116..12960768)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ovate family protein 17 Neighboring gene ovate family protein 2 Neighboring gene ncRNA Neighboring gene Homeodomain-like superfamily protein Neighboring gene Homeodomain-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallization and preliminary X-ray analysis of tubulin-folding cofactor A from Arabidopsis thaliana. Lu L, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Aug 1. PMID 20693679, Free PMC Article
    2. The Arabidopsis TUBULIN-FOLDING COFACTOR A gene is involved in the control of the alpha/beta-tubulin monomer balance. Kirik V, et al. Plant Cell, 2002 Sep. PMID 12215519, Free PMC Article
    3. Crystal structure of tubulin folding cofactor A from Arabidopsis thaliana and its beta-tubulin binding characterization. Lu L, et al. FEBS Lett, 2010 Aug 20. PMID 20638386
    4. The Arabidopsis PILZ group genes encode tubulin-folding cofactor orthologs required for cell division but not cell growth. Steinborn K, et al. Genes Dev, 2002 Apr 15. PMID 11959844, Free PMC Article
    5. Toward an interaction map of the two-component signaling pathway of Arabidopsis thaliana. Dortay H, et al. J Proteome Res, 2008 Sep. PMID 18642946

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001202711.2
    NM_128594.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables beta-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokinesis by cell plate formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in post-chaperonin tubulin folding pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tubulin complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tubulin complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in peroxisome HDA PubMed 

    General protein information

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    Preferred Names
    tubulin folding cofactor A (KIESEL)
    NP_001189640.1
    • KIESEL (KIS); FUNCTIONS IN: unfolded protein binding; INVOLVED IN: tubulin complex assembly, cytokinesis; LOCATED IN: microtubule; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Tubulin binding cofactor A (InterPro:IPR004226).
    NP_001318319.1
    • KIESEL (KIS); FUNCTIONS IN: unfolded protein binding; INVOLVED IN: tubulin complex assembly, cytokinesis; LOCATED IN: microtubule; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Tubulin binding cofactor A (InterPro:IPR004226); Has 359 Blast hits to 359 proteins in 168 species: Archae - 0; Bacteria - 0; Metazoa - 159; Fungi - 92; Plants - 60; Viruses - 0; Other Eukaryotes - 48 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      12958116..12960768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336255.1 → NP_001318319.1  tubulin folding cofactor A (KIESEL) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04350, Q547H3, Q949R2
      UniProtKB/TrEMBL
      A0A178VY81, A0A5S9X2M7, A0A7G2EC90
      Conserved Domains (1) summary
      pfam02970
      Location:7 → 90
      TBCA; Tubulin binding cofactor A

    2. NM_001202711.2 → NP_001189640.1  tubulin folding cofactor A (KIESEL) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189640.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04350, Q547H3, Q949R2
      UniProtKB/TrEMBL
      A0A178VY81, A0A5S9X2M7, A0A7G2EC90
      Conserved Domains (1) summary
      pfam02970
      Location:7 → 90
      TBCA; Tubulin binding cofactor A

    3. NM_128594.4 → NP_565699.1  tubulin folding cofactor A (KIESEL) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565699.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04350, Q547H3, Q949R2
      UniProtKB/TrEMBL
      A0A178VY81, A0A5S9X2M7, A0A7G2EC90
      Conserved Domains (1) summary
      pfam02970
      Location:7 → 90
      TBCA; Tubulin binding cofactor A
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04350.2

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