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    cldn1 claudin 1 [ Danio rerio (zebrafish) ]

    Gene ID: 81590, updated on 12-Sep-2024

    Summary

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    Official Symbol
    cldn1provided by ZNC
    Official Full Name
    claudin 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010328-11
    See related
    AllianceGenome:ZFIN:ZDB-GENE-010328-11
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cldn19
    Summary
    Predicted to enable structural molecule activity. Predicted to be involved in bicellular tight junction assembly and cell adhesion. Predicted to be located in cell junction and membrane. Predicted to be integral component of membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in eye; gill; integument; ovary; and posterior intestine. Human ortholog(s) of this gene implicated in Crohn's disease and atopic dermatitis. Orthologous to human CLDN1 (claudin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See cldn1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (68788..71962)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (45314..48488, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene tensin-3 Neighboring gene zgc:153913 Neighboring gene NAD-dependent protein deacylase sirtuin-5, mitochondrial Neighboring gene phosphatase and actin regulator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Reactive oxygen species participate in liver function recovery during compensatory growth in zebrafish (Danio rerio). Jia J, et al. Biochem Biophys Res Commun, 2018 May 5. PMID 29574160
    2. A novel transgenic zebrafish model for blood-brain and blood-retinal barrier development. Xie J, et al. BMC Dev Biol, 2010 Jul 23. PMID 20653957, Free PMC Article
    3. Exogenous GDF9 but not Activin A, BMP15 or TGFβ alters tight junction protein transcript abundance in zebrafish ovarian follicles. Clelland ES, et al. Gen Comp Endocrinol, 2011 Apr 1. PMID 21291886
    4. Thymol and Carvacrol Affect Hybrid Tilapia through the Combination of Direct Stimulation and an Intestinal Microbiota-Mediated Effect: Insights from a Germ-Free Zebrafish Model. Ran C, et al. J Nutr, 2016 May. PMID 27075912
    5. Voltage-gated sodium channel scn8a is required for innervation and regeneration of amputated adult zebrafish fins. Osorio-Méndez D, et al. Proc Natl Acad Sci U S A, 2022 Jul 12. PMID 35867745, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicellular tight junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    claudin-1
    Names
    claudin 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131770.1 → NP_571845.1  claudin-1 precursor

      See identical proteins and their annotated locations for NP_571845.1

      Status: PROVISIONAL

      Source sequence(s)
      AF359436
      UniProtKB/TrEMBL
      Q90XQ8
      Conserved Domains (1) summary
      cl21598
      Location:24 → 182
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      68788..71962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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