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    AL6 alfin-like 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814776, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AL6
    Official Full Name
    alfin-like 6
    Primary source
    TAIR:AT2G02470
    Locus tag
    AT2G02470
    See related
    Araport:AT2G02470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    alfin-like 6; T16F16.26; T16F16_26
    Summary
    Encodes a member of the Alfin1-like family of nuclear-localized PHD (plant homeodomain) domain containing proteins that acts as a novel upstream regulator of root hair formation during Pi starvation. All AL proteins except AL3 bind to di- or trimethylated histone H3 (H3K4me3/2). Members of this family include: AT5G05610 (AL1), AT3G11200 (AL2), AT3G42790 (AL3), AT5G26210 (AL4), AT5G20510 (AL5), AT2G02470 (AL6), AT1G14510 (AL7).
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    Genomic context

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    See AL6 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Sequence:
    Chromosome: 2; NC_003071.7 (652564..654985)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NAC domain containing protein 35 Neighboring gene AAA-type ATPase family protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chromatin enrichment for proteomics in plants (ChEP-P) implicates the histone reader ALFIN-LIKE 6 in jasmonate signalling. Vélez-Bermúdez IC, et al. BMC Genomics, 2021 Nov 22. PMID 34809577, Free PMC Article
    2. A PHD in histone language: on the role of histone methylation in plant responses to phosphate deficiency. Chandrika NN, et al. Plant Signal Behav, 2013 Jun. PMID 23531693, Free PMC Article
    3. ALFIN-LIKE 6 is involved in root hair elongation during phosphate deficiency in Arabidopsis. Chandrika NNP, et al. New Phytol, 2013 May. PMID 23432399
    4. The Alfin-like homeodomain finger protein AL5 suppresses multiple negative factors to confer abiotic stress tolerance in Arabidopsis. Wei W, et al. Plant J, 2015 Mar. PMID 25619813
    5. Arabidopsis AL PHD-PRC1 complexes promote seed germination through H3K4me3-to-H3K27me3 chromatin state switch in repression of seed developmental genes. Molitor AM, et al. PLoS Genet, 2014 Jan. PMID 24465219, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chromatin enrichment for proteomics in plants (ChEP-P) implicates the histone reader ALFIN-LIKE 6 in jasmonate signalling.
      Title: Chromatin enrichment for proteomics in plants (ChEP-P) implicates the histone reader ALFIN-LIKE 6 in jasmonate signalling.
    2. AL6 contains a plant homeo domain finger that can bind to trimethylated lysine 4 of histone H3
      Title: A PHD in histone language: on the role of histone methylation in plant responses to phosphate deficiency.
    3. we propose that AL PHD-PRC1 complexes(AL6 and AL7 ), built around H3K4me3, lead to a switch from the H3K4me3-associated active to the H3K27me3-associated repressive transcription state of seed developmental genes during seed germination.
      Title: Arabidopsis AL PHD-PRC1 complexes promote seed germination through H3K4me3-to-H3K27me3 chromatin state switch in repression of seed developmental genes.
    4. AL6 controls the transcription of a suite of genes critical for root hair elongation under low phosphate conditions.
      Title: ALFIN-LIKE 6 is involved in root hair elongation during phosphate deficiency in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001202573.2
    NM_001335119.1
    NM_126302.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to phosphate starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular monoatomic cation homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within root hair elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    alfin-like 6
    NP_001189502.1
    • alfin-like 6 (AL6); CONTAINS InterPro DOMAIN/s: Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, PHD-type (InterPro:IPR001965), Protein of unknown function DUF3594 (InterPro:IPR021998), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, PHD-finger (InterPro:IPR019787); BEST Arabidopsis thaliana protein match is: alfin-like 7 (TAIR:AT1G14510.1).
    NP_178351.1
    • alfin-like 6 (AL6); CONTAINS InterPro DOMAIN/s: Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, PHD-type (InterPro:IPR001965), Protein of unknown function DUF3594 (InterPro:IPR021998), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, PHD-finger (InterPro:IPR019787); BEST Arabidopsis thaliana protein match is: alfin-like 7 (TAIR:AT1G14510.1); Has 1820 Blast hits to 1777 proteins in 193 species: Archae - 0; Bacteria - 0; Metazoa - 798; Fungi - 350; Plants - 563; Viruses - 0; Other Eukaryotes - 109 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      652564..654985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202573.2 → NP_001189502.1  alfin-like 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189502.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VSB3, A0A5S9WWM8, A0A654ERA8
      Conserved Domains (2) summary
      cd15613
      Location:194 → 243
      PHD_AL_plant; PHD finger found in plant Alfin1-like (AL) proteins
      pfam12165
      Location:12 → 139
      Alfin

    2. NM_001335119.1 → NP_001323925.1  alfin-like 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AYM4

    3. NM_126302.3 → NP_178351.1  alfin-like 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178351.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IQE0, Q8LAH0, Q8S8M9
      UniProtKB/TrEMBL
      A0A178VQJ7, A0A5S9WWM8, A0A654ERA8
      Conserved Domains (2) summary
      cd15613
      Location:203 → 252
      PHD_AL_plant; PHD finger found in plant Alfin1-like (AL) proteins
      pfam12165
      Location:12 → 139
      Alfin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8S8M9.1

    Gene LinkOut

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