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    Fabp7 fatty acid binding protein 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 80841, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fabp7provided by RGD
    Official Full Name
    fatty acid binding protein 7provided by RGD
    Primary source
    RGD:69312
    See related
    AllianceGenome:RGD:69312
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable fatty acid binding activity. Involved in epithelial cell proliferation. Predicted to be located in several cellular components, including cell projection; cell-cell junction; and neuronal cell body. Predicted to be active in cytosol and nucleus. Orthologous to human FABP7 (fatty acid binding protein 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 1507.3) and Brain (RPKM 463.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fabp7 in Genome Data Viewer
    Location:
    20q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (37667125..37673299)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (37123193..37126725)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (40769624..40773156)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene serine incorporator 1 Neighboring gene uncharacterized LOC134483929 Neighboring gene cAMP-dependent protein kinase inhibitor beta Neighboring gene sphingomyelin phosphodiesterase, acid-like 3A Neighboring gene LIM/homeobox protein Lhx5-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Brain lipid-binding protein promotes proliferation and modulates cell cycle in C6 rat glioma cells. Han X, et al. Int J Oncol, 2017 Nov. PMID 29048614, Free PMC Article
    2. Astrocyte fatty acid binding protein-7 is a marker for neurogenic niches in the rat hippocampus. Young JK, et al. Hippocampus, 2013 Dec. PMID 23996503, Free PMC Article
    3. Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. Liang Y, et al. Proc Natl Acad Sci U S A, 2005 Apr 19. PMID 15827123, Free PMC Article
    4. Cloning and characterization of a cDNA encoding a novel fatty acid binding protein from rat brain. Bennett E, et al. J Neurochem, 1994 Nov. PMID 7931318
    5. Role of Fabp7, a downstream gene of Pax6, in the maintenance of neuroepithelial cells during early embryonic development of the rat cortex. Arai Y, et al. J Neurosci, 2005 Oct 19. PMID 16237179, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results of the xenograft model assay showed that exogenous BLBP also stimulated tumor formation and downregulated p21 and p16. In conclusion, our study demonstrated that exogenous BLBP promoted proliferation of the C6 cells in vitro and facilitated tumor formation in vivo. Therefore, BLBP expression in glioma cells may promote cell growth by inhibiting the tumor suppressors.
      Title: Brain lipid-binding protein promotes proliferation and modulates cell cycle in C6 rat glioma cells.
    2. The data of this study suggested that regional accumulations of FABP7+ astrocytes may represent reservoirs of cells having the potential for neurogenesis.
      Title: Astrocyte fatty acid binding protein-7 is a marker for neurogenic niches in the rat hippocampus.
    3. Fabp7 is a downstream gene of Pax6 transcription factor in the developing rat cortex and essential for maintenance of neuroepithelial cells during early cortical development.
      Title: Role of Fabp7, a downstream gene of Pax6, in the maintenance of neuroepithelial cells during early embryonic development of the rat cortex.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell proliferation in forebrain ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within prepulse inhibition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within startle response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fatty acid-binding protein, brain
    Names
    B-FABP
    BLBP
    brain lipid-binding protein
    brain-type fatty acid-binding protein
    fatty acid binding protein 7, brain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030832.2 → NP_110459.1  fatty acid-binding protein, brain

      See identical proteins and their annotated locations for NP_110459.1

      Status: PROVISIONAL

      Source sequence(s)
      U02096
      UniProtKB/Swiss-Prot
      P55051
      UniProtKB/TrEMBL
      A6K4D4, A6K4D5
      Conserved Domains (1) summary
      cl10502
      Location:2 → 131
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      37667125..37673299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279555.1 → XP_063135625.1  fatty acid-binding protein, brain isoform X1

      UniProtKB/Swiss-Prot
      P55051
      UniProtKB/TrEMBL
      A6K4D4

    2. XM_063279556.1 → XP_063135626.1  fatty acid-binding protein, brain isoform X1

      UniProtKB/Swiss-Prot
      P55051
      UniProtKB/TrEMBL
      A6K4D4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55051.2 GenPept UniProtKB/Swiss-Prot:P55051

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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