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    grik5 glutamate receptor, ionotropic, kainate 5 [ Danio rerio (zebrafish) ]

    Gene ID: 798791, updated on 12-Sep-2024

    Summary

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    Official Symbol
    grik5provided by ZNC
    Official Full Name
    glutamate receptor, ionotropic, kainate 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070821-6
    See related
    Ensembl:ENSDARG00000101449 AllianceGenome:ZFIN:ZDB-GENE-070821-6
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to act upstream of or within ion transport. Predicted to be located in membrane and synapse. Predicted to be integral component of membrane. Predicted to be active in postsynaptic membrane. Is expressed in brain; eye; retinal inner plexiform layer; retinal outer plexiform layer; and retinal photoreceptor layer. Orthologous to human GRIK5 (glutamate ionotropic receptor kainate type subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See grik5 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (11361832..11555934)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (11470673..11665032)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene glycogen synthase kinase 3 alpha b Neighboring gene zinc finger protein 574 Neighboring gene uncharacterized LOC110437970 Neighboring gene si:dkey-11o1.3 Neighboring gene zgc:198329

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. GRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish. Unlu G, et al. Am J Hum Genet, 2019 Mar 7. PMID 30827500, Free PMC Article
    2. Excessive activation of ionotropic glutamate receptors induces apoptotic hair-cell death independent of afferent and efferent innervation. Sheets L. Sci Rep, 2017 Jan 23. PMID 28112265, Free PMC Article
    3. Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. Kuretani A, et al. BMC Ecol Evol, 2021 Jul 29. PMID 34325655, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kainate selective glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of kainate selective glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutamate receptor ionotropic, kainate 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328156.1 → NP_001315085.1  glutamate receptor ionotropic, kainate 5 precursor

      Status: VALIDATED

      Source sequence(s)
      BX005242, CR388405
      UniProtKB/TrEMBL
      A0A0R4IG83, A0A8M1P3L5
      Related
      ENSDARP00000133431.1, ENSDART00000169012.2
      Conserved Domains (5) summary
      cd06394
      Location:38 → 412
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam00060
      Location:558 → 828
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:55 → 392
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:313 → 383
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
      cl21456
      Location:427 → 797
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      11361832..11555934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009292105.4 → XP_009290380.1  glutamate receptor ionotropic, kainate 5 isoform X1

      See identical proteins and their annotated locations for XP_009290380.1

      UniProtKB/TrEMBL
      A0A0R4IG83, A0A8M1P3L5
      Conserved Domains (5) summary
      cd06394
      Location:38 → 412
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam00060
      Location:558 → 828
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:55 → 392
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:313 → 383
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
      cl21456
      Location:427 → 797
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    2. XM_009292107.4 → XP_009290382.1  glutamate receptor ionotropic, kainate 5 isoform X3

      UniProtKB/TrEMBL
      A0A140LH73, A0A8M3AIX5
      Related
      ENSDARP00000142603.1, ENSDART00000173042.2
      Conserved Domains (5) summary
      cd06394
      Location:38 → 412
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam00060
      Location:558 → 828
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:55 → 392
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:313 → 383
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
      cl21456
      Location:427 → 797
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    3. XM_068214037.1 → XP_068070138.1  glutamate receptor ionotropic, kainate 5 isoform X2

    4. XM_068214036.1 → XP_068070137.1  glutamate receptor ionotropic, kainate 5 isoform X1

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394954.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      2324..27526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001245961.1: Suppressed sequence

      Description
      NM_001245961.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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