eda ectodysplasin A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: edaprovided by ZNC
Official Full Name: ectodysplasin Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050107-6
See related: Ensembl:ENSDARG00000074591 AllianceGenome:ZFIN:ZDB-GENE-050107-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nkt; nackt; tnfsf19; si:ch73-223d24.5
Summary: Predicted to enable receptor ligand activity. Acts upstream of or within bone development and odontogenesis. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in dental mesenchyme; head; integument; and pharynx. Human ortholog(s) of this gene implicated in ectodermal dysplasia 1 and tooth agenesis. Orthologous to human EDA (ectodysplasin A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (36439405..36499030)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (35839252..35898877)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Eda and edar are not required for early development but are specific for the development of adult skeletal and dental structures.
Title: Zebrafish eda and edar mutants reveal conserved and ancestral roles of ectodysplasin signaling in vertebrates.

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General gene information

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Markers

z28270 (e-PCR), detects polymorphism
- UniSTS:238979

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables receptor ligand activity	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within bone development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within odontogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ectodysplasin-A

Names: TNF superfamily member 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001115065.1 → NP_001108537.1 ectodysplasin-A

See identical proteins and their annotated locations for NP_001108537.1

Status: PROVISIONAL

Source sequence(s)

EF137866

UniProtKB/TrEMBL

B0YIF1

Related

ENSDARP00000093748.3, ENSDART00000102973.5

Conserved Domains (1) summary

cl00147
Location:214 → 346

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...