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    MOB3B MOB kinase activator 3B [ Homo sapiens (human) ]

    Gene ID: 79817, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MOB3Bprovided by HGNC
    Official Full Name
    MOB kinase activator 3Bprovided by HGNC
    Primary source
    HGNC:HGNC:23825
    See related
    Ensembl:ENSG00000120162 MIM:617652; AllianceGenome:HGNC:23825
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MOB1D; C9orf35; MOBKL2B
    Summary
    The protein encoded by this gene shares similarity with the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. This gene is located on the opposite strand as the interferon kappa precursor (IFNK) gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 14.2), duodenum (RPKM 9.8) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MOB3B in Genome Data Viewer
    Location:
    9p21.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (27325209..27529814, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (27335803..27540380, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (27325207..27529812, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:27251147-27251648 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:27251649-27252148 Neighboring gene RNA exonuclease 6, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:27279903-27280404 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:27303550-27304050 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:27304051-27304551 Neighboring gene equatorin Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:27353610-27354591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28253 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:27369079-27369832 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:27369833-27370587 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:27395570-27396133 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:27465247-27465748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19819 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:27494687-27495392 Neighboring gene dapper homolog 3-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19821 Neighboring gene Sharpr-MPRA regulatory region 13504 Neighboring gene interferon kappa Neighboring gene C9orf72-SMCR8 complex subunit Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19822 Neighboring gene chromosome 9 open reading frame 72 repeat instability region Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:27573561-27574088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:27610369-27610870 Neighboring gene CTAGE family member 12, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics. Kim EA, et al. J Korean Med Sci, 2015 Jul. PMID 26130958, Free PMC Article
    2. A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer. Kerns SL, et al. J Urol, 2013 Jul. PMID 23376709
    3. Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood. Joung J, et al. Nature, 2017 Aug 17. PMID 28792927, Free PMC Article
    4. Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study. Suarez-Gestal M, et al. Arthritis Res Ther, 2010. PMID 20423481, Free PMC Article
    5. Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis. Liu C, et al. Mol Med, 2008 Sep-Oct. PMID 18615156, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. low levels of hMOB3B are closely associated with aggressive clinicopathologic features in patients with prostate cancer. The results suggest that hMOB3B may act as a tumor suppressor in human prostate cancer.
      Title: Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics.
    2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer.
    EBI GWAS Catalog
    Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13204, FLJ23916, MGC32960

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MOB kinase activator 3B
    Names
    MOB kinase activator-like 2B
    MOB1, Mps One Binder kinase activator-like 2B
    mob1 homolog 2b
    monopolar spindle 1 binding, MOB1, domain containing
    mps one binder kinase activator-like 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024761.5 → NP_079037.3  MOB kinase activator 3B

      See identical proteins and their annotated locations for NP_079037.3

      Status: REVIEWED

      Source sequence(s)
      AK023266, AL163192, BF511468, CN260547, DB266074
      Consensus CDS
      CCDS6520.1
      UniProtKB/Swiss-Prot
      Q86TA1, Q8NEB4, Q9H8V4
      Related
      ENSP00000262244.5, ENST00000262244.6
      Conserved Domains (1) summary
      pfam03637
      Location:35 → 207
      Mob1_phocein; Mob1/phocein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      27325209..27529814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423892.1 → XP_047279848.1  MOB kinase activator 3B isoform X1

      UniProtKB/Swiss-Prot
      Q86TA1, Q8NEB4, Q9H8V4

    2. XM_047423895.1 → XP_047279851.1  MOB kinase activator 3B isoform X1

      UniProtKB/Swiss-Prot
      Q86TA1, Q8NEB4, Q9H8V4

    3. XM_047423894.1 → XP_047279850.1  MOB kinase activator 3B isoform X1

      UniProtKB/Swiss-Prot
      Q86TA1, Q8NEB4, Q9H8V4

    4. XM_047423891.1 → XP_047279847.1  MOB kinase activator 3B isoform X1

      UniProtKB/Swiss-Prot
      Q86TA1, Q8NEB4, Q9H8V4

    5. XM_047423893.1 → XP_047279849.1  MOB kinase activator 3B isoform X1

      UniProtKB/Swiss-Prot
      Q86TA1, Q8NEB4, Q9H8V4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      27335803..27540380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363858.1 → XP_054219833.1  MOB kinase activator 3B isoform X1

      UniProtKB/Swiss-Prot
      Q86TA1, Q8NEB4, Q9H8V4

    2. XM_054363860.1 → XP_054219835.1  MOB kinase activator 3B isoform X1

      UniProtKB/Swiss-Prot
      Q86TA1, Q8NEB4, Q9H8V4

    3. XM_054363857.1 → XP_054219832.1  MOB kinase activator 3B isoform X1

      UniProtKB/Swiss-Prot
      Q86TA1, Q8NEB4, Q9H8V4

    4. XM_054363859.1 → XP_054219834.1  MOB kinase activator 3B isoform X1

      UniProtKB/Swiss-Prot
      Q86TA1, Q8NEB4, Q9H8V4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86TA1.2 GenPept UniProtKB/Swiss-Prot:Q86TA1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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