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    cabp4 calcium binding protein 4 [ Danio rerio (zebrafish) ]

    Gene ID: 797905, updated on 14-Nov-2024

    Summary

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    Official Symbol
    cabp4provided by ZNC
    Official Full Name
    calcium binding protein 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081104-291
    See related
    Ensembl:ENSDARG00000008866 AllianceGenome:ZFIN:ZDB-GENE-081104-291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch73-56f16.1
    Summary
    Predicted to enable calcium channel regulator activity. Predicted to be active in cytoplasm. Is expressed in retinal photoreceptor layer. Orthologous to human CABP4 (calcium binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See cabp4 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (13794785..13823146, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (13757067..13785462, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100536890 Neighboring gene LON peptidase N-terminal domain and ring finger 1 Neighboring gene double C2-like domains, gamma Neighboring gene serpin peptidase inhibitor, clade G (C1 inhibitor), member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular phylogeny of C1 inhibitor depicts two immunoglobulin-like domains fusion in fishes and ray-finned fishes specific intron insertion after separation from zebrafish. Kumar A, et al. Biochem Biophys Res Commun, 2014 Jul 18. PMID 24878530
    2. Characterization of the calcium binding protein family in zebrafish. Di Donato V, et al. PLoS One, 2013. PMID 23341937, Free PMC Article
    3. Transcripts within rod photoreceptors of the Zebrafish retina. Sun C, et al. BMC Genomics, 2018 Feb 8. PMID 29422031, Free PMC Article
    4. Regulation of spermatogonial development by Fsh: The complementary roles of locally produced Igf and Wnt signaling molecules in adult zebrafish testis. Safian D, et al. Gen Comp Endocrinol, 2019 Dec 1. PMID 31415728
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calcium-binding protein 4
    Names
    cabp4a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328057.1 → NP_001314986.1  calcium-binding protein 4

      Status: VALIDATED

      Source sequence(s)
      EH443700
      UniProtKB/TrEMBL
      A0A286Y9G4, A0A8M1P9U5
      Related
      ENSDARP00000143613.2, ENSDART00000177174.2
      Conserved Domains (3) summary
      cd00051
      Location:164 → 227
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:165 → 223
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:91 → 148
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      13794785..13823146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166913.5 → XP_005166970.1  calcium-binding protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BEY0
      Conserved Domains (3) summary
      cd00051
      Location:163 → 226
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:164 → 222
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:90 → 147
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. XM_021478326.2 → XP_021334001.1  calcium-binding protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QDW6
      Conserved Domains (1) summary
      cl25352
      Location:129 → 264
      EFh_PEF; The penta-EF hand (PEF) family

    3. XM_021478325.2 → XP_021334000.1  calcium-binding protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QIQ8
      Conserved Domains (1) summary
      cl25352
      Location:130 → 265
      EFh_PEF; The penta-EF hand (PEF) family
    Nucleotide Protein Strain
    Heading Accession and Version

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