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    Stmn4 stathmin 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79423, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Stmn4provided by RGD
    Official Full Name
    stathmin 4provided by RGD
    Primary source
    RGD:69349
    See related
    EnsemblRapid:ENSRNOG00000053334 AllianceGenome:RGD:69349
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rb3; Lagl
    Summary
    Predicted to enable tubulin binding activity. Predicted to be involved in microtubule depolymerization; neuron projection development; and regulation of microtubule polymerization or depolymerization. Predicted to be located in Golgi apparatus and growth cone. Predicted to be active in cytoplasm and neuron projection. Orthologous to human STMN4 (stathmin 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 200.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stmn4 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (44716825..44734776)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (40541305..40559253)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (43007901..43025852)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene microRNA 6320 Neighboring gene tripartite motif-containing 35 Neighboring gene adrenoceptor alpha 1A Neighboring gene dihydropyrimidinase-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Selective upregulation of RB3/stathmin4 by ciliary neurotrophic factor following optic nerve axotomy. Nakazawa T, et al. Brain Res, 2005 Nov 9. PMID 16256088
    2. Modulation of the stathmin-like microtubule destabilizing activity of RB3, a neuron-specific member of the SCG10 family, by its N-terminal domain. Nakao C, et al. J Biol Chem, 2004 May 28. PMID 15039434
    3. The stathmin family -- molecular and biological characterization of novel mammalian proteins expressed in the nervous system. Ozon S, et al. Eur J Biochem, 1997 Sep 15. PMID 9342231
    4. Differential, regional, and cellular expression of the stathmin family transcripts in the adult rat brain. Ozon S, et al. J Neurosci Res, 1999 Jun 1. PMID 10369222
    5. SCLIP: a novel SCG10-like protein of the stathmin family expressed in the nervous system. Ozon S, et al. J Neurochem, 1998 Jun. PMID 9603203

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. regulatory role of the unique N-terminal domain of RB3 in microtubule dynamics would contribute to the physiological regulation of neuronal morphogenesis
      Title: Modulation of the stathmin-like microtubule destabilizing activity of RB3, a neuron-specific member of the SCG10 family, by its N-terminal domain.
    2. RB3 is the unique response protein in the stathmin-related proteins following optic nerve axotomy and the induced RB3 may play a critical role in the CNTF-induced response on the axotomized retinal ganglion cells
      Title: Selective upregulation of RB3/stathmin4 by ciliary neurotrophic factor following optic nerve axotomy.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109417

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    stathmin-4
    Names
    stathmin-like 4
    stathmin-like protein B3
    stathmin-like-protein RB3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270855.1 → NP_001257784.1  stathmin-4 isoform b

      See identical proteins and their annotated locations for NP_001257784.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate exon in the 3' end compared to variant 1. This exon has an in-frame stop codon, resulting in an isoform (b) with a shorter and distinct C-terminus compared to isoform a. Variants 2 and 6 both encode the same isoform (b).
      Source sequence(s)
      BC092646, JAXUCZ010000015
      UniProtKB/TrEMBL
      Q568Y8
      Conserved Domains (1) summary
      pfam00836
      Location:76 → 203
      Stathmin; Stathmin family

    2. NM_001270856.1 → NP_001257785.1  stathmin-4 isoform c

      See identical proteins and their annotated locations for NP_001257785.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC092646, JAXUCZ010000015
      UniProtKB/Swiss-Prot
      P63043
      UniProtKB/TrEMBL
      A6K6M7, A6K6M9
      Conserved Domains (1) summary
      pfam00836
      Location:49 → 184
      Stathmin; Stathmin family

    3. NM_001270857.1 → NP_001257786.1  stathmin-4 isoform d

      See identical proteins and their annotated locations for NP_001257786.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 5' end of the next exon compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC092646, JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K6M7
      Related
      ENSRNOP00000069450.2, ENSRNOT00000087709.3
      Conserved Domains (1) summary
      pfam00836
      Location:48 → 183
      Stathmin; Stathmin family

    4. NM_001270858.1 → NP_001257787.1  stathmin-4 isoform e

      See identical proteins and their annotated locations for NP_001257787.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon and has an alternate exon in the 3' end compared to variant 1. This additional exon has an in-frame stop codon, resulting in an isoform (e) with a shorter and distinct C-terminus and lacking an alternate internal segment compared to isoform a.
      Source sequence(s)
      BC092646, JAXUCZ010000015
      UniProtKB/Swiss-Prot
      P63043
      UniProtKB/TrEMBL
      Q568Y8
      Related
      ENSRNOP00000108777.1, ENSRNOT00000158569.1
      Conserved Domains (1) summary
      pfam00836
      Location:49 → 176
      Stathmin; Stathmin family

    5. NM_001270859.1 → NP_001257788.1  stathmin-4 isoform b

      See identical proteins and their annotated locations for NP_001257788.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and has an alternate exon in the 3' end compared to variant 1. This exon has an in-frame stop codon, resulting in an isoform (b) with a shorter and distinct C-terminus compared to isoform a. Variants 2 and 6 both encode the same isoform (b).
      Source sequence(s)
      BC092646, CB580507
      UniProtKB/TrEMBL
      Q568Y8
      Related
      ENSRNOP00000072524.1, ENSRNOT00000084753.3
      Conserved Domains (1) summary
      pfam00836
      Location:76 → 203
      Stathmin; Stathmin family

    6. NM_019176.2 → NP_062049.1  stathmin-4 isoform a

      See identical proteins and their annotated locations for NP_062049.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC092646, JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K6M6, A6K6M7
      Conserved Domains (1) summary
      pfam00836
      Location:76 → 211
      Stathmin; Stathmin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      44716825..44734776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008770778.3 → XP_008769000.1  stathmin-4 isoform X2

      UniProtKB/TrEMBL
      A6K6M7
      Conserved Domains (1) summary
      pfam00836
      Location:75 → 210
      Stathmin; Stathmin family

    2. XM_063274689.1 → XP_063130759.1  stathmin-4 isoform X5

    3. XM_063274678.1 → XP_063130748.1  stathmin-4 isoform X1

      UniProtKB/TrEMBL
      A6K6M6

    4. XM_039093677.2 → XP_038949605.1  stathmin-4 isoform X1

      UniProtKB/TrEMBL
      A6K6M6, A6K6M7
      Conserved Domains (1) summary
      pfam00836
      Location:76 → 211
      Stathmin; Stathmin family

    5. XM_063274681.1 → XP_063130751.1  stathmin-4 isoform X2

    6. XM_063274687.1 → XP_063130757.1  stathmin-4 isoform X4

    7. XM_063274686.1 → XP_063130756.1  stathmin-4 isoform X4

    8. XM_063274683.1 → XP_063130753.1  stathmin-4 isoform X3

      UniProtKB/Swiss-Prot
      P63043
      UniProtKB/TrEMBL
      A6K6M9

    9. XM_063274682.1 → XP_063130752.1  stathmin-4 isoform X3

      UniProtKB/Swiss-Prot
      P63043
      UniProtKB/TrEMBL
      A6K6M9

    10. XM_039093679.1 → XP_038949607.1  stathmin-4 isoform X4

      UniProtKB/TrEMBL
      A6K6M7
      Conserved Domains (1) summary
      pfam00836
      Location:48 → 183
      Stathmin; Stathmin family

    11. XM_063274684.1 → XP_063130754.1  stathmin-4 isoform X3

      UniProtKB/Swiss-Prot
      P63043
      UniProtKB/TrEMBL
      A6K6M9

    12. XM_063274679.1 → XP_063130749.1  stathmin-4 isoform X1

      UniProtKB/TrEMBL
      A6K6M6

    13. XM_063274680.1 → XP_063130750.1  stathmin-4 isoform X1

      UniProtKB/TrEMBL
      A6K6M6
      Related
      ENSRNOP00000073294.1, ENSRNOT00000091567.3

    14. XM_063274685.1 → XP_063130755.1  stathmin-4 isoform X3

      UniProtKB/Swiss-Prot
      P63043
      UniProtKB/TrEMBL
      A6K6M9

    15. XM_063274688.1 → XP_063130758.1  stathmin-4 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63043.1 GenPept UniProtKB/Swiss-Prot:P63043

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