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    mgrn1a mahogunin, ring finger 1a [ Danio rerio (zebrafish) ]

    Gene ID: 793939, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mgrn1aprovided by ZNC
    Official Full Name
    mahogunin, ring finger 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6192
    See related
    Ensembl:ENSDARG00000100072 AllianceGenome:ZFIN:ZDB-GENE-030131-6192
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mgrn1; zgc:55978; wu:fi38c03
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in endosome to lysosome transport; negative regulation of signal transduction; and protein ubiquitination. Predicted to be active in early endosome; nucleus; and plasma membrane. Orthologous to human MGRN1 (mahogunin ring finger 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See mgrn1a in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (20122461..20147764)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (20000587..20025890)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene lipopolysaccharide-induced tumor necrosis factor-alpha factor-like Neighboring gene UBA-like domain containing 1a Neighboring gene forkhead box J1b Neighboring gene rhomboid 5 homolog 1b (Drosophila)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Global transcriptomic analysis of zebrafish in response to embryonic exposure to three antidepressants, amitriptyline, fluoxetine and mianserin. Wu M, et al. Aquat Toxicol, 2017 Nov. PMID 28992598
    2. Pigmentation pathway evolution after whole-genome duplication in fish. Braasch I, et al. Genome Biol Evol, 2009 Nov 25. PMID 20333216, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0544, MGC55978, MGC174549

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase MGRN1
    Names
    RING-type E3 ubiquitin transferase MGRN1
    mahogunin RING finger protein 1
    mahogunin, ring finger 1
    NP_001315473.1
    NP_956173.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328544.1 → NP_001315473.1  probable E3 ubiquitin-protein ligase MGRN1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC159204, CR456632, EB903247, EH435644, EH461643
      UniProtKB/Swiss-Prot
      Q7ZUL9
      UniProtKB/TrEMBL
      A0A8M1PAF7, B7ZVH3
      Related
      ENSDARP00000140478.1, ENSDART00000168364.2
      Conserved Domains (2) summary
      PHA02929
      Location:230 → 329
      PHA02929; N1R/p28-like protein; Provisional
      pfam13920
      Location:275 → 317
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    2. NM_199879.2 → NP_956173.2  probable E3 ubiquitin-protein ligase MGRN1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      BC159204, CR456632
      UniProtKB/Swiss-Prot
      Q7ZUL9
      UniProtKB/TrEMBL
      A0A8M1PEQ1, B0JZJ6
      Related
      ENSDARP00000132672.1, ENSDART00000161505.2
      Conserved Domains (2) summary
      PHA02929
      Location:230 → 329
      PHA02929; N1R/p28-like protein; Provisional
      pfam13920
      Location:272 → 317
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      20122461..20147764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZUL9.1 GenPept UniProtKB/Swiss-Prot:Q7ZUL9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.