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    ldlrap1b low density lipoprotein receptor adaptor protein 1b [ Danio rerio (zebrafish) ]

    Gene ID: 791153, updated on 12-Sep-2024

    Summary

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    Official Symbol
    ldlrap1bprovided by ZNC
    Official Full Name
    low density lipoprotein receptor adaptor protein 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070112-1012
    See related
    Ensembl:ENSDARG00000039750 AllianceGenome:ZFIN:ZDB-GENE-070112-1012
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:158745
    Summary
    Predicted to be active in early endosome. Human ortholog(s) of this gene implicated in autosomal recessive hypercholesterolemia. Orthologous to human LDLRAP1 (low density lipoprotein receptor adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See ldlrap1b in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (45582382..45649312)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (45458875..45491955, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene Rh blood group, D antigen Neighboring gene macoilin 1b Neighboring gene collagen alpha-6(VI) chain Neighboring gene fibronectin type III domain containing 5a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary conservation of maternal RNA localization in fishes and amphibians revealed by TOMO-Seq. Naraine R, et al. Dev Biol, 2022 Sep. PMID 35752299
    2. Spatio-temporal expression and distribution of collagen VI during zebrafish development. Tonelotto V, et al. Sci Rep, 2019 Dec 27. PMID 31882701, Free PMC Article
    3. Evolutionary and Expression Analyses Show Co-option of khdrbs Genes for Origin of Vertebrate Brain. Wang S, et al. Front Genet, 2017. PMID 29354154, Free PMC Article
    4. Transcriptional and metabolic effects of glucocorticoid receptor α and β signaling in zebrafish. Chatzopoulou A, et al. Endocrinology, 2015 May. PMID 25756310
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    low density lipoprotein receptor adapter protein 1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080635.1 → NP_001074104.1  low density lipoprotein receptor adapter protein 1b

      See identical proteins and their annotated locations for NP_001074104.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129425
      UniProtKB/TrEMBL
      A1L2A8
      Related
      ENSDARP00000058092.7, ENSDART00000058093.7
      Conserved Domains (1) summary
      cd13159
      Location:43 → 165
      PTB_LDLRAP-mammal-like; Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) in mammals and similar proteins Phosphotyrosine-binding (PTB) PH-like fold

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      45582382..45649312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480671.2 → XP_021336346.1  low density lipoprotein receptor adapter protein 1b isoform X1

      UniProtKB/TrEMBL
      A0A8M9QJV1
      Conserved Domains (1) summary
      cd13159
      Location:43 → 165
      PTB_LDLRAP-mammal-like; Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) in mammals and similar proteins Phosphotyrosine-binding (PTB) PH-like fold
    Nucleotide Protein Strain
    Heading Accession and Version

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