Csf1 colony stimulating factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Csf1provided by RGD
Official Full Name: colony stimulating factor 1provided by RGD
Primary source: RGD:621063
See related: EnsemblRapid:ENSRNOG00000018659 AllianceGenome:RGD:621063
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PG-M-CSF
Summary: Enables identical protein binding activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; myeloid leukocyte differentiation; and positive regulation of macrophage proliferation. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; high grade glioma; and osteopetrosis. Biomarker of systemic scleroderma. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 138.7), Lung (RPKM 62.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (198065400..198084774, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (195377215..195396608, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (210522370..210550546, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studied the molecular basis for M-CSF-induced ROS generation and RANK expression in the early stages of osteoclastic differentiation. Generation of ROS by M-CSF was mediated by Nox2 and was required for the expression of RANK associated with ERK.
Title: A crucial role for reactive oxygen species in macrophage colony-stimulating factor-induced RANK expression in osteoclastic differentiation.
This study showed increase in the C-fibre response and an upregulation of the gene expression of csf1 180 minutes after application of NP onto the nerve roots.
Title: Spinal nociceptive hyperexcitability induced by experimental disc herniation is associated with enhanced local expression of Csf1 and FasL.
Excessive fluoride induces an accelerated bone turnover and may promote the absorption activity of osteoclasts by increasing the expression of OPGL and M-CSF.
Title: [The influence of fluoride on expression of OPGL and M-CSF genes and their proteins in rats with experimental fluorosis and the therapeutic effect of Danlan Xianpeng Liaofu caspule].
Upregulated macrophage-colony stimulating factor causes microglia to proliferate in axotomized facial nerve.
Title: Macrophage-colony stimulating factor as an inducer of microglial proliferation in axotomized rat facial nucleus.
CSF-1 promotes angiogenesis at the chondroosseous junction
Title: Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections.
The early upregulation of MCSF/CSF-1R signaling may be an important regulatory pathway among neurons, microglia, and glia in diabetic retinopathy.
Title: Expression of macrophage colony-stimulating factor (M-CSF) and its receptor in streptozotocin-induced diabetic rats.
CSF-1 has a role in the development of osteoclasts
Title: The effects of colony-stimulating factor-1 (CSF-1) on the development of osteoclasts and their expression of tartrate-resistant acid phosphatase (TRAP) in toothless (tl-osteopetrotic) rats.
Molecular mechanism by which CSF-1-dependent alkalinization increases osteoclast survival may be associated with inhibition of caspase-8 and -3. NBCn1 may be novel therapeutic target for preventing pathological bone loss.
Title: Colony-stimulating factor-1 increases osteoclast intracellular pH and promotes survival via the electroneutral Na/HCO3 cotransporter NBCn1.
role for CSF-1 in osteoclastogenesis and endochondral ossification
Title: The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification.
Csf-1 implicated not only in its well-established role in regulating osteoclastic bone resorption, but also in endochondral ossification.
Title: A new histomorphometric method to assess growth plate chondrodysplasia and its application to the toothless (tl, Csf1(null)) osteopetrotic rat.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

PMC137879P1 (e-PCR)
- UniSTS:270857

D3Mit104.1 (e-PCR), detects polymorphism
- UniSTS:129503

CSF1 (e-PCR)
- UniSTS:278247

PMC101742P1 (e-PCR)
- UniSTS:270063

AI547928 (e-PCR)
- UniSTS:240367

AI176011 (e-PCR)
- UniSTS:260606

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables macrophage colony-stimulating factor receptor binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to parathyroid hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in developmental process involved in reproduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in macrophage differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in macrophage differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of macrophage differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within macrophage homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary duct terminal end bud growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland fat development	ISO Inferred from Sequence Orthology more info
involved_in microglial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of monocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monocyte homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of myeloid leukocyte migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutrophil homeostasis	ISO Inferred from Sequence Orthology more info
involved_in ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoclast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoclast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage colony-stimulating factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage derived foam cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macrophage differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of microglial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of microglial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of monocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mononuclear cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mononuclear cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mononuclear cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
involved_in response to ischemia	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CSF1-CSF1R complex	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: macrophage colony-stimulating factor 1

Names: CSF-1; MCSF; colony stimulating factor 1 (macrophage); proteoglycan macrophage colony-stimulating factor

NP_076471.3

EC 2.7.10.1

XP_006233249.1

EC 2.7.10.1

XP_008759648.1

EC 2.7.10.1

XP_008759650.1

EC 2.7.10.1

XP_008759651.1

EC 2.7.10.1

XP_017446614.1

EC 2.7.10.1

XP_038959101.1

EC 2.7.10.1

XP_038959102.1

EC 2.7.10.1

XP_063138667.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023981.4 → NP_076471.3 macrophage colony-stimulating factor 1 precursor

See identical proteins and their annotated locations for NP_076471.3

Status: PROVISIONAL

Source sequence(s)

BC074007

UniProtKB/Swiss-Prot

Q8JZQ0

UniProtKB/TrEMBL

A6HUV1, Q6GMN4

Conserved Domains (1) summary

pfam05337
Location:265 → 566

CSF-1; Macrophage colony stimulating factor-1 (CSF-1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

198065400..198084774 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103173.2 → XP_038959101.1 macrophage colony-stimulating factor 1 isoform X5

Conserved Domains (1) summary

pfam05337
Location:40 → 206

CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
XM_063282597.1 → XP_063138667.1 macrophage colony-stimulating factor 1 isoform X6
XM_008761426.4 → XP_008759648.1 macrophage colony-stimulating factor 1 isoform X1

Conserved Domains (1) summary

pfam05337
Location:292 → 566

CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
XM_008761428.4 → XP_008759650.1 macrophage colony-stimulating factor 1 isoform X2

UniProtKB/TrEMBL

A0A0G2K4Q6

Related

ENSRNOP00000097151.2, ENSRNOT00000111860.2

Conserved Domains (1) summary

pfam05337
Location:265 → 539

CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
XM_039103174.2 → XP_038959102.1 macrophage colony-stimulating factor 1 isoform X7

UniProtKB/TrEMBL

A6HUV3

Conserved Domains (1) summary

pfam05337
Location:40 → 206

CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
XM_017591125.3 → XP_017446614.1 macrophage colony-stimulating factor 1 isoform X4

UniProtKB/Swiss-Prot

Q8JZQ0

UniProtKB/TrEMBL

A0A8L2QDI9, A6HUV1

Related

ENSRNOP00000025221.6, ENSRNOT00000025222.8

Conserved Domains (1) summary

pfam05337
Location:292 → 593

CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
XM_008761429.4 → XP_008759651.1 macrophage colony-stimulating factor 1 isoform X3

UniProtKB/TrEMBL

A0A0G2K4Q6

Conserved Domains (1) summary

pfam05337
Location:292 → 566

CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
XM_006233187.4 → XP_006233249.1 macrophage colony-stimulating factor 1 isoform X4

UniProtKB/Swiss-Prot

Q8JZQ0

UniProtKB/TrEMBL

A0A8L2QDI9, A6HUV1

Conserved Domains (1) summary

pfam05337
Location:292 → 593

CSF-1; Macrophage colony stimulating factor-1 (CSF-1)