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    LIG4 DNA ligase 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 781252, updated on 4-Oct-2024

    Summary

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    Official Symbol
    LIG4provided by VGNC
    Official Full Name
    DNA ligase 4provided by VGNC
    Primary source
    VGNC:VGNC:30884
    See related
    BGD:BT20764; Ensembl:ENSBTAG00000015868
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See LIG4 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 12 NC_037339.1 (83594743..83602542, complement)

    Chromosome 12 - NC_037339.1Genomic Context describing neighboring genes Neighboring gene NALCN channel auxiliary factor 1 Neighboring gene non-histone chromosomal protein HMG-17-like Neighboring gene uncharacterized LOC132346798 Neighboring gene abhydrolase domain containing 13 Neighboring gene TNF superfamily member 13b

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037339.1 Chromosome 12 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA ligase (ATP) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in DNA ligation involved in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin V(D)J recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nucleotide-excision repair, DNA gap filling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA ligase IV complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of DNA-dependent protein kinase-DNA ligase 4 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA ligase 4
    NP_001178055.1
    XP_005214056.1
    XP_005214060.1
    XP_010809288.1
    XP_024855766.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191126.1 → NP_001178055.1  DNA ligase 4

      See identical proteins and their annotated locations for NP_001178055.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000012
      UniProtKB/TrEMBL
      A0A3Q1MFZ7, F1MB07
      Conserved Domains (3) summary
      TIGR00574
      Location:81 → 602
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:655 → 730
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam11411
      Location:750 → 783
      DNA_ligase_IV; DNA ligase IV

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037339.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      83594743..83602542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010810986.4 → XP_010809288.1  DNA ligase 4 isoform X1

      See identical proteins and their annotated locations for XP_010809288.1

      UniProtKB/TrEMBL
      A0A3Q1MFZ7, F1MB07
      Related
      ENSBTAP00000089404.1, ENSBTAT00000099981.1
      Conserved Domains (3) summary
      TIGR00574
      Location:81 → 602
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:655 → 730
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam11411
      Location:750 → 783
      DNA_ligase_IV; DNA ligase IV

    2. XM_005214003.5 → XP_005214060.1  DNA ligase 4 isoform X2

      See identical proteins and their annotated locations for XP_005214060.1

      UniProtKB/TrEMBL
      A0A3Q1MFZ7
      Conserved Domains (3) summary
      TIGR00574
      Location:14 → 535
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:588 → 663
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam11411
      Location:683 → 716
      DNA_ligase_IV; DNA ligase IV

    3. XM_024999998.2 → XP_024855766.1  DNA ligase 4 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MFZ7
      Conserved Domains (3) summary
      TIGR00574
      Location:14 → 535
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:588 → 663
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam11411
      Location:683 → 716
      DNA_ligase_IV; DNA ligase IV

    4. XM_005213999.4 → XP_005214056.1  DNA ligase 4 isoform X1

      See identical proteins and their annotated locations for XP_005214056.1

      UniProtKB/TrEMBL
      A0A3Q1MFZ7, F1MB07
      Related
      ENSBTAP00000021092.4, ENSBTAT00000021092.6
      Conserved Domains (3) summary
      TIGR00574
      Location:81 → 602
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:655 → 730
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam11411
      Location:750 → 783
      DNA_ligase_IV; DNA ligase IV
    Nucleotide Protein Strain
    Heading Accession and Version

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