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    ADORA3 adenosine A3 receptor [ Bos taurus (domestic cattle) ]

    Gene ID: 780806, updated on 12-Oct-2024

    Summary

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    Official Symbol
    ADORA3provided by VGNC
    Official Full Name
    adenosine A3 receptorprovided by VGNC
    Primary source
    VGNC:VGNC:54876
    See related
    Ensembl:ENSBTAG00000039738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Summary
    This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors involved in a variety of intracellular signaling pathways and physiological functions. Studies of orthologous proteins suggest that the receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it may have neuroprotective and neurodegenerative effects, and it may also mediate cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:104564307, which encodes a transmembrane and immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]
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    Genomic context

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    See ADORA3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (31810361..31814235)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene RAP1A, member of RAS oncogene family Neighboring gene uncharacterized LOC101903375 Neighboring gene transmembrane and immunoglobulin domain containing 3 Neighboring gene chromosome 3 C1orf162 homolog Neighboring gene ATP synthase peripheral stalk-membrane subunit b

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization. Hill SJ, et al. Br J Pharmacol, 2014 Mar. PMID 24024783, Free PMC Article
    2. G protein-coupled receptors and adipogenesis: a focus on adenosine receptors. Eisenstein A, et al. J Cell Physiol, 2014 Apr. PMID 24114647, Free PMC Article
    3. A3 receptor ligands: past, present and future trends. Taliani S, et al. Curr Top Med Chem, 2010. PMID 20370658
    4. The A3 adenosine receptor: an enigmatic player in cell biology. Gessi S, et al. Pharmacol Ther, 2008 Jan. PMID 18029023
    5. The adenosine A3 receptor and its ligands. van Muijlwijk-Koezen JE, et al. Prog Med Chem, 2001. PMID 11774799

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC133776, MGC142828

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled adenosine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled adenosine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenosine receptor A3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001104611.2 → NP_001098081.1  adenosine receptor A3 isoform 1

      See identical proteins and their annotated locations for NP_001098081.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC120305, CO894234, DY460588
      UniProtKB/Swiss-Prot
      Q0VC81
      Related
      ENSBTAP00000010057.4, ENSBTAT00000010057.6
      Conserved Domains (2) summary
      pfam00001
      Location:29 → 281
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:21 → 127
      7tm_4; Olfactory receptor

    2. NM_001302768.1 → NP_001289697.1  adenosine receptor A3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate segment in the 5' UTR and 5' coding region, resulting in translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC120305, CO894234, FE014702
      UniProtKB/TrEMBL
      A0AAA9THT5
      Related
      ENSBTAP00000096456.1, ENSBTAT00000108423.1
      Conserved Domains (2) summary
      cd14964
      Location:31 → 53
      7tm_GPCRs; TM helix 3 [structural motif]
      cl28897
      Location:1 → 239
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      31810361..31814235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VC81.1 GenPept UniProtKB/Swiss-Prot:Q0VC81

    Gene LinkOut

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