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    nup98 nucleoporin 98 and 96 precursor [ Danio rerio (zebrafish) ]

    Gene ID: 777756, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nup98provided by ZNC
    Official Full Name
    nucleoporin 98 and 96 precursorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1180
    See related
    Ensembl:ENSDARG00000074955 AllianceGenome:ZFIN:ZDB-GENE-040426-1180
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63593; im:7151238; zgc:113968
    Summary
    Predicted to enable RNA binding activity and nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Acts upstream of or within enteric nervous system development. Predicted to be located in nuclear membrane. Predicted to be part of nuclear pore cytoplasmic filaments. Is expressed in central nervous system and intestine. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Orthologous to human NUP98 (nucleoporin 98 and 96 precursor). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nup98 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (40354781..40398640, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (40331228..40375135, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene odorant receptor, family 6, subfamily AT, member 1 Neighboring gene neuronal acetylcholine receptor subunit alpha-10 Neighboring gene uncharacterized LOC100534731 Neighboring gene small nucleolar RNA SNORD65 Neighboring gene small nucleolar RNA SNORD65

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Role of a novel zebrafish nup98 during embryonic development. Fung TK, et al. Exp Hematol, 2010 Nov. PMID 20696206
    2. Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes. Gui H, et al. Genome Biol, 2017 Mar 8. PMID 28274275, Free PMC Article
    3. Attributing effects of aqueous C60 nano-aggregates to tetrahydrofuran decomposition products in larval zebrafish by assessment of gene expression. Henry TB, et al. Environ Health Perspect, 2007 Jul. PMID 17637923, Free PMC Article
    4. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63593, MGC173990

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within enteric nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere tethering at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore cytoplasmic filaments IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear pore complex protein Nup98-Nup96

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200685.2 → NP_956979.2  nuclear pore complex protein Nup98-Nup96

      Status: VALIDATED

      Source sequence(s)
      CR847523
      UniProtKB/TrEMBL
      A0A8M1PHK6, E7F981
      Related
      ENSDARP00000110413.3, ENSDART00000130950.3
      Conserved Domains (3) summary
      pfam04096
      Location:741 → 881
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:1333 → 1626
      Nup96; Nuclear protein 96
      pfam13634
      Location:39 → 133
      Nucleoporin_FG; Nucleoporin FG repeat region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      40354781..40398640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161439.5 → XP_005161496.1  nuclear pore complex protein Nup98-Nup96 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IAQ8, A0A8M2B8E5
      Related
      ENSDARP00000131290.2, ENSDART00000162500.2
      Conserved Domains (3) summary
      pfam04096
      Location:734 → 874
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:1326 → 1619
      Nup96; Nuclear protein 96
      pfam13634
      Location:39 → 133
      Nucleoporin_FG; Nucleoporin FG repeat region

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001077797.1: Suppressed sequence

      Description
      NM_001077797.1: This RefSeq was permanently suppressed because it was based on chimeric sequence.
    Nucleotide Protein Strain
    Heading Accession and Version

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