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    TNPO1 transportin 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 767620, updated on 12-Oct-2024

    Summary

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    Official Symbol
    TNPO1provided by VGNC
    Official Full Name
    transportin 1provided by VGNC
    Primary source
    VGNC:VGNC:36199
    See related
    Ensembl:ENSBTAG00000007979
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    TRN; KPNB2
    Orthologs
    human mouse all
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    Genomic context

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    See TNPO1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (8722813..8816681, complement)

    Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene FCH and mu domain containing endocytic adaptor 2 Neighboring gene uncharacterized LOC132343204 Neighboring gene uncharacterized LOC132343203 Neighboring gene uncharacterized LOC132343205 Neighboring gene H2B.L histone variant 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of nuclear localization signal-importin α interaction by Ca2+/S100A6. Takata M, et al. FEBS Lett, 2010 Nov 19. PMID 20965181
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC127455

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear localization sequence binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transportin-1
    Names
    importin beta-2
    karyopherin (importin) beta 2
    karyopherin beta-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076540.1 → NP_001070008.1  transportin-1

      See identical proteins and their annotated locations for NP_001070008.1

      Status: PROVISIONAL

      Source sequence(s)
      BC103374
      UniProtKB/TrEMBL
      A0A3Q1MP13
      Related
      ENSBTAP00000010491.6, ENSBTAT00000010491.7
      Conserved Domains (2) summary
      COG5215
      Location:24 → 759
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:95 → 116
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      8722813..8816681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024981409.2 → XP_024837177.1  transportin-1 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MP13
      Related
      ENSBTAP00000073075.2, ENSBTAT00000076134.2
      Conserved Domains (2) summary
      COG5215
      Location:32 → 741
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:103 → 124
      HEAT; HEAT repeat [structural motif]

    2. XM_059878803.1 → XP_059734786.1  transportin-1 isoform X1

    3. XM_059878802.1 → XP_059734785.1  transportin-1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3SYU7.2 GenPept UniProtKB/Swiss-Prot:Q3SYU7

    Gene LinkOut

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