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    CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 [ Ovis aries (sheep) ]

    Gene ID: 767576, updated on 10-Oct-2024

    Summary

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    Gene symbol
    CYP11B1
    Gene description
    cytochrome P450, family 11, subfamily B, polypeptide 1
    See related
    EnsemblRapid:ENSOARG00020013254
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
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    Genomic context

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    See CYP11B1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 9 NC_056062.1 (14477140..14485010, complement)

    Chromosome 9 - NC_056062.1Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member E Neighboring gene lymphocyte antigen 6I-like Neighboring gene glycosylphosphatidylinositol anchored molecule like Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene cytochrome P450 11B1, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056062.1 Chromosome 9 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of an ovine CYP11B1 gene. Anwar A, et al. DNA Seq, 1998. PMID 10728821
    2. Cloning and expression analysis of a cytochrome P-450(11 beta) cDNA in sheep. Boon WC, et al. Biochim Biophys Acta, 1995 Jan 2. PMID 7999785
    3. Molecular cloning and characterization of the ovine CYP11B1 promoter. Anwar A, et al. Biochem Mol Biol Int, 1994 Aug. PMID 7804143
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables corticosterone 18-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables steroid 11-beta-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aldosterone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to peptide hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cortisol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glucocorticoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome P450 11B1, mitochondrial
    Names
    CYPXIB1
    cytochrome P450C11
    steroid 11-beta-hydroxylase, CYP11B1
    steroid hydroxylase
    NP_001068568.1
    XP_027828557.1
    XP_060275904.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075100.2 → NP_001068568.1  cytochrome P450 11B1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001068568.1

      Status: PROVISIONAL

      Source sequence(s)
      U78477
      UniProtKB/Swiss-Prot
      O19181, P51663
      UniProtKB/TrEMBL
      A0A836D0A1
      Related
      ENSOARP00020017139.1, ENSOART00020020700.2
      Conserved Domains (1) summary
      pfam00067
      Location:42 → 499
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056062.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      14477140..14485010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_060419921.1 → XP_060275904.1  cytochrome P450 11B1, mitochondrial isoform X2

    2. XM_027972756.3 → XP_027828557.1  cytochrome P450 11B1, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      O19181, P51663
      UniProtKB/TrEMBL
      A0A836D0A1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51663.2 GenPept UniProtKB/Swiss-Prot:P51663

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials