Slc38a3 solute carrier family 38, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc38a3provided by MGI
Official Full Name: solute carrier family 38, member 3provided by MGI
Primary source: MGI:MGI:1923507
See related: Ensembl:ENSMUSG00000010064 AllianceGenome:MGI:1923507
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sn1; Nat1; mNAT; Snat3; D9Ucla2; Slc38-3; 0610012J02Rik
Summary: Enables L-asparagine, sodium:proton antiporter activity; L-glutamine, sodium:proton antiporter activity; and L-histidine, sodium:proton antiporter activity. Involved in carboxylic acid transport and intracellular amino acid homeostasis. Acts upstream of or within carboxylic acid transport; cellular response to potassium ion starvation; and positive regulation of transcription by RNA polymerase II. Located in apical plasma membrane. Is expressed in several structures, including central nervous system; metanephros; pancreas; pericardium; and retina. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 102. Orthologous to human SLC38A3 (solute carrier family 38 member 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in liver adult (RPKM 1073.0), liver E18 (RPKM 123.2) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 58.69 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (107528353..107546167, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (107651154..107668968, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Choroid plexus LAT2 and SNAT3 as partners in CSF amino acid homeostasis maintenance.
Title: Choroid plexus LAT2 and SNAT3 as partners in CSF amino acid homeostasis maintenance.
the results demonstrate the regulatory role of Sp1 in regulation of SN1 expression and activity in ammonia-treated astrocytes and implicate altered Sp1 phosphorylation status in this capacity.
Title: Silencing of Transcription Factor Sp1 Promotes SN1 Transporter Regulation by Ammonia in Mouse Cortical Astrocytes.
This indicates a role for PKC in dynamically controlling the trafficking of SNAT3 transporters in astrocytes in situ.
Title: PKC-Mediated Modulation of Astrocyte SNAT3 Glutamine Transporter Function at Synapses in Situ.
SNAT3 is required for amino acid homeostasis and determines critical functions in various organs. Loss of Snat3 cannot be compensated.
Title: Loss of function mutation of the Slc38a3 glutamine transporter reveals its critical role for amino acid metabolism in the liver, brain, and kidney.
acid loading increased urinary ammonium excretion in all groups, but to a lesser extent in the O-GI group. SNAT3 mRNA expression was enhanced in both obese groups
Title: Dysregulation of the glutamine transporter Slc38a3 (SNAT3) and ammoniagenic enzymes in obese, glucose-intolerant mice.
Regulation of SNAT3 gene expression by extracellular pH involves post-transcriptional and transcriptional mechanisms, the latter being distinct from the mechanisms that control the tissue-specific expression of the gene
Title: Expression of glutamine transporter Slc38a3 (SNAT3) during acidosis is mediated by a different mechanism than tissue-specific expression.
In this study, the in vivo endothelial membrane localization of the sodium-dependent glutamine transporters Snat3 (Slc38a3) and Snat1 (Slc38a1) was investigated in the mouse brain microvasculature.
Title: Differential axial localization along the mouse brain vascular tree of luminal sodium-dependent glutamine transporters Snat1 and Snat3.
Potassium restriction, high protein intake, and metabolic acidosis increase expression of the glutamine transporter SNAT3 (Slc38a3) in mouse kidney.
Title: Potassium restriction, high protein intake, and metabolic acidosis increase expression of the glutamine transporter SNAT3 (Slc38a3) in mouse kidney.
ISH and IF revealed SN1 and SN2 expression in the ganglion, inner nuclear, and photoreceptor cell layers.
Title: Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells.
selective regulation of SNAT3 and y(+)LAT1 expression may serve a major role in the renal adaptation to acid secretion and thus for systemic acid-base balance.
Title: Regulation of renal amino acid transporters during metabolic acidosis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc38a3 (e-PCR), detects polymorphism
- UniSTS:547340

D9Dcr102 (e-PCR), detects polymorphism
- UniSTS:499004

NoName (e-PCR)
- UniSTS:236245

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-alanine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-asparagine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-asparagine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-asparagine, sodium:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-asparagine, sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables L-glutamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glutamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-glutamine, sodium:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glutamine, sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables L-histidine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-histidine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-histidine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-histidine, sodium:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-histidine, sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-alanine transport	IEA Inferred from Electronic Annotation more info
involved_in L-alanine transport	ISO Inferred from Sequence Orthology more info
involved_in L-asparagine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-asparagine import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-glutamine import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in L-glutamine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-glutamine import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-histidine import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in L-histidine transport	ISO Inferred from Sequence Orthology more info
involved_in L-histidine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in asparagine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in asparagine transport	ISO Inferred from Sequence Orthology more info
involved_in asparagine transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to potassium ion starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info
involved_in glutamine secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamine secretion	ISO Inferred from Sequence Orthology more info
involved_in glutamine secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutamine transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glutamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamine transport	ISO Inferred from Sequence Orthology more info
involved_in histidine transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within histidine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in histidine transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular amino acid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glutamine transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glutamine transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium-coupled neutral amino acid transporter 3

Names: N system amino acids transporter NAT-1; N-system amino acid transporter 1; Na(+)-coupled neutral amino acid transporter 3; system N amino acid transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199217.1 → NP_001186146.1 sodium-coupled neutral amino acid transporter 3

See identical proteins and their annotated locations for NP_001186146.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.

Source sequence(s)

AK002607, BC054846, CJ183778

Consensus CDS

CCDS23503.1

UniProtKB/Swiss-Prot

Q8BS53, Q9DCP2, Q9JLL8

Related

ENSMUSP00000142087.2, ENSMUST00000193932.6

Conserved Domains (1) summary

pfam01490
Location:63 → 492

Aa_trans; Transmembrane amino acid transporter protein
NM_001199218.1 → NP_001186147.1 sodium-coupled neutral amino acid transporter 3

See identical proteins and their annotated locations for NP_001186147.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.

Source sequence(s)

BC055339

Consensus CDS

CCDS23503.1

UniProtKB/Swiss-Prot

Q8BS53, Q9DCP2, Q9JLL8

Related

ENSMUSP00000137561.2, ENSMUST00000177567.8

Conserved Domains (1) summary

pfam01490
Location:63 → 492

Aa_trans; Transmembrane amino acid transporter protein
NM_023805.3 → NP_076294.2 sodium-coupled neutral amino acid transporter 3

See identical proteins and their annotated locations for NP_076294.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.

Source sequence(s)

BC054846, CJ183778

Consensus CDS

CCDS23503.1

UniProtKB/Swiss-Prot

Q8BS53, Q9DCP2, Q9JLL8

Related

ENSMUSP00000010208.9, ENSMUST00000010208.14

Conserved Domains (1) summary

pfam01490
Location:63 → 492

Aa_trans; Transmembrane amino acid transporter protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

107528353..107546167 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155378.1 → XP_036011271.1 sodium-coupled neutral amino acid transporter 3 isoform X1

UniProtKB/Swiss-Prot

Q8BS53, Q9DCP2, Q9JLL8

Conserved Domains (1) summary

pfam01490
Location:63 → 492

Aa_trans; Transmembrane amino acid transporter protein
XM_030244697.1 → XP_030100557.1 sodium-coupled neutral amino acid transporter 3 isoform X1

UniProtKB/Swiss-Prot

Q8BS53, Q9DCP2, Q9JLL8

Related

ENSMUSP00000130414.2, ENSMUST00000167868.8

Conserved Domains (1) summary

pfam01490
Location:63 → 492

Aa_trans; Transmembrane amino acid transporter protein
XM_030244696.2 → XP_030100556.1 sodium-coupled neutral amino acid transporter 3 isoform X1

UniProtKB/Swiss-Prot

Q8BS53, Q9DCP2, Q9JLL8

Conserved Domains (1) summary

pfam01490
Location:63 → 492

Aa_trans; Transmembrane amino acid transporter protein