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    Rab11fip2 RAB11 family interacting protein 2 (class I) [ Mus musculus (house mouse) ]

    Gene ID: 74998, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rab11fip2provided by MGI
    Official Full Name
    RAB11 family interacting protein 2 (class I)provided by MGI
    Primary source
    MGI:MGI:1922248
    See related
    Ensembl:ENSMUSG00000040022 AllianceGenome:MGI:1922248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nrip11; 4930470G04Rik; A830046J09Rik
    Summary
    Predicted to enable protein homodimerization activity and protein kinase binding activity. Involved in insulin secretion involved in cellular response to glucose stimulus and regulated exocytosis. Predicted to be located in nucleoplasm. Predicted to be active in endosome and phagocytic cup. Is expressed in nephric duct of male and telencephalon ventricular layer. Orthologous to human RAB11FIP2 (RAB11 family interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 5.3), CNS E18 (RPKM 5.1) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rab11fip2 in Genome Data Viewer
    Location:
    19 D3; 19 56.28 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (59881934..59933086, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (59893502..59943656, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46662 Neighboring gene predicted gene, 46660 Neighboring gene STARR-seq mESC enhancer starr_46593 Neighboring gene VISTA enhancer mm449 Neighboring gene predicted gene, 41879 Neighboring gene predicted gene, 41880

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rab11FIP1-deficient mice develop spontaneous inflammation and show increased susceptibility to colon damage. Rathan-Kumar S, et al. Am J Physiol Gastrointest Liver Physiol, 2022 Sep 1. PMID 35819177, Free PMC Article
    2. Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking. Matthies HJ, et al. J Neurosci, 2010 Jun 9. PMID 20534835, Free PMC Article
    3. Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity. Wang Z, et al. Cell, 2008 Oct 31. PMID 18984164, Free PMC Article
    4. Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors. Cullis DN, et al. J Biol Chem, 2002 Dec 20. PMID 12364336
    5. Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis. Sugawara K, et al. Genes Cells, 2009 Apr. PMID 19335615

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data demonstrate that AMPH leads to an increase of NET in endosomes of single boutons and varicosities in a Rab11-dependent manner.
      Title: Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking.
    2. Rab11-FIP2 has a role in the coupling of receptor-mediated endocytosis to the subsequent sorting of receptor-containing vesicles in endosomes [RAB11-FIP2]
      Title: Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in TRAM-dependent toll-like receptor 4 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in TRAM-dependent toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulated exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulated exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in phagocytic cup IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic cup IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagocytic cup ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rab11 family-interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033172.3 → NP_001028344.2  rab11 family-interacting protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001028344.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC105061, AC162855, BC089010
      Consensus CDS
      CCDS38033.1
      UniProtKB/TrEMBL
      Q3U366
      Related
      ENSMUSP00000059978.7, ENSMUST00000051996.13
      Conserved Domains (2) summary
      cd08682
      Location:15 → 141
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      pfam09457
      Location:452 → 499
      RBD-FIP; FIP domain

    2. NM_001164367.1 → NP_001157839.1  rab11 family-interacting protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001157839.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant also contains an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC105061, AC162855, AK015534, BC089010
      Consensus CDS
      CCDS50482.1
      UniProtKB/TrEMBL
      G3UW57
      Related
      ENSMUSP00000128813.2, ENSMUST00000171986.8
      Conserved Domains (1) summary
      pfam09457
      Location:310 → 357
      RBD-FIP; FIP domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      59881934..59933086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247386.4 → XP_011245688.1  rab11 family-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B9EID4, G3XA57, Q5HZI0
      Conserved Domains (2) summary
      cd08682
      Location:15 → 141
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      pfam09457
      Location:452 → 499
      RBD-FIP; FIP domain

    2. XM_036161718.1 → XP_036017611.1  rab11 family-interacting protein 2 isoform X2

      Conserved Domains (2) summary
      pfam09457
      Location:348 → 395
      RBD-FIP; FIP domain
      cl14603
      Location:14 → 37
      C2; C2 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3XA57.1 GenPept UniProtKB/Swiss-Prot:G3XA57

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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