Glyr1 glyoxylate reductase 1 homolog (Arabidopsis) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Glyr1provided by MGI
Official Full Name: glyoxylate reductase 1 homolog (Arabidopsis)provided by MGI
Primary source: MGI:MGI:1921272
See related: Ensembl:ENSMUSG00000022536 AllianceGenome:MGI:1921272
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NDF; Npac; 2810419J22Rik; 3930401K13Rik
Summary: Enables DNA binding activity and chromatin binding activity. Predicted to be involved in transcription elongation-coupled chromatin remodeling and transcription initiation-coupled chromatin remodeling. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be part of nucleosome. Is expressed in several structures, including central nervous system; early conceptus; gonad; and retina. Used to study atrioventricular septal defect. Orthologous to human GLYR1 (glyoxylate reductase 1 homolog). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E14 (RPKM 46.0), whole brain E14.5 (RPKM 44.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 2.49 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (4831766..4867780, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (5013902..5049938, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of nucleosome-destabilizing factor GLYR1 dampens spermatogenesis in mice.
Title: Deficiency of nucleosome-destabilizing factor GLYR1 dampens spermatogenesis in mice.
Npac Is A Co-factor of Histone H3K36me3 and Regulates Transcriptional Elongation in Mouse Embryonic Stem Cells.
Title: Npac Is A Co-factor of Histone H3K36me3 and Regulates Transcriptional Elongation in Mouse Embryonic Stem Cells.
Transcription factor protein interactomes reveal genetic determinants in heart disease.
Title: Transcription factor protein interactomes reveal genetic determinants in heart disease.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D20S544E (e-PCR)
- UniSTS:43298

NoName (e-PCR)
- UniSTS:237418

NoName (e-PCR)
- UniSTS:237420

AW545332 (e-PCR)
- UniSTS:180848

MARC_17251-17252:1024677488:1 (e-PCR)
- UniSTS:268268

MARC_17251-17252:1032365658:1 (e-PCR)
- UniSTS:268268

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin-protein adaptor activity	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleosome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in transcription elongation-coupled chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription elongation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
part_of nucleosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytokine-like nuclear factor N-PAC

Names: cytokine-like nuclear factor n-pac; nuclear protein NP60; putative oxidoreductase GLYR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079814.1 → NP_001073282.1 cytokine-like nuclear factor N-PAC isoform 1

See identical proteins and their annotated locations for NP_001073282.1

Status: VALIDATED

Source sequence(s)

AC163723, AI854082, AK151832, BY135011, CF174076

Consensus CDS

CCDS37244.1

UniProtKB/TrEMBL

D3YYT1

Related

ENSMUSP00000111510.2, ENSMUST00000115844.3

Conserved Domains (3) summary

cd05836
Location:6 → 90

N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...

COG2084
Location:267 → 550

MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]

cl25423
Location:209 → 301

NAD_bind_amino_acid_DH; NAD(P) binding domain of amino acid dehydrogenase-like proteins
NM_001359747.1 → NP_001346676.1 cytokine-like nuclear factor N-PAC isoform 3

Status: VALIDATED

Source sequence(s)

AC163723

Conserved Domains (2) summary

COG2084
Location:198 → 475

MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]

cl02554
Location:1 → 21

PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
NM_001359748.1 → NP_001346677.1 cytokine-like nuclear factor N-PAC isoform 4

Status: VALIDATED

Source sequence(s)

AC163723

Conserved Domains (3) summary

COG2084
Location:198 → 481

MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]

cl02554
Location:1 → 21

PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

cl25423
Location:140 → 232

NAD_bind_amino_acid_DH; NAD(P) binding domain of amino acid dehydrogenase-like proteins
NM_028720.2 → NP_082996.2 cytokine-like nuclear factor N-PAC isoform 2

See identical proteins and their annotated locations for NP_082996.2

Status: VALIDATED

Source sequence(s)

AI854082, AK152887, AK159476, BY135011

Consensus CDS

CCDS27930.1

UniProtKB/Swiss-Prot

Q3TX02, Q922P9, Q9CYQ1

Related

ENSMUSP00000023189.8, ENSMUST00000023189.15

Conserved Domains (2) summary

cd05836
Location:6 → 90

N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...

COG2084
Location:267 → 544

MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

4831766..4867780 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030249304.2 → XP_030105164.1 cytokine-like nuclear factor N-PAC isoform X2

Conserved Domains (2) summary

cd05836
Location:6 → 90

N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...

COG2084
Location:187 → 464

MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
XM_030249303.2 → XP_030105163.1 cytokine-like nuclear factor N-PAC isoform X1

Conserved Domains (3) summary

cd05836
Location:6 → 90

N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...

COG2084
Location:187 → 470

MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]

cl21454
Location:129 → 221

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_036160153.1 → XP_036016046.1 cytokine-like nuclear factor N-PAC isoform X3

Conserved Domains (2) summary

cd05836
Location:6 → 90

N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...

cl21454
Location:268 → 349

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins