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    Spmip7 sperm microtubule inner protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 73862, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Spmip7provided by MGI
    Official Full Name
    sperm microtubule inner protein 7provided by MGI
    Primary source
    MGI:MGI:1921112
    See related
    Ensembl:ENSMUSG00000020191 AllianceGenome:MGI:1921112
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spata48; 4930415F15Rik
    Summary
    Involved in spermatogenesis. Orthologous to human SPMIP7 (sperm microtubule inner protein 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 2.9) and limb E14.5 (RPKM 0.2) See more
    Orthologs
    human all
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    Genomic context

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    See Spmip7 in Genome Data Viewer
    Location:
    11 A1; 11 6.93 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (11412089..11465658)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (11463744..11515192)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zona pellucida binding protein Neighboring gene predicted gene, 26458 Neighboring gene TGF beta-inducible nuclear protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr11:11361594-11361894 Neighboring gene STARR-positive B cell enhancer ABC_E10664 Neighboring gene STARR-positive B cell enhancer ABC_E8871 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11428864-11429017 Neighboring gene STARR-positive B cell enhancer ABC_E2348 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11464295-11464600 Neighboring gene STARR-seq mESC enhancer starr_28596 Neighboring gene predicted gene, 29945 Neighboring gene predicted gene 11998 Neighboring gene RIKEN cDNA 4930512M02 gene Neighboring gene STARR-seq mESC enhancer starr_28597

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comparison of the sensitivity of C57BL/6J and AKR/J mice to airborne molecules of isovaleric acid and amyl acetate. Pourtier L, et al. Behav Genet, 1990 Jul. PMID 2175173
    2. Spermatogenesis-associated 48 is essential for spermatogenesis in mice. Zhang J, et al. Andrologia, 2018 Aug. PMID 29700843
    3. Fidgetin-like1 is a strong candidate for a dynamic impairment of male meiosis leading to reduced testis weight in mice. L'Hôte D, et al. PLoS One, 2011. PMID 22110678, Free PMC Article
    4. Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy. Brody MJ, et al. PLoS One, 2012. PMID 23236519, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In humans and mice with azoospermia, expression of SPATA48 disappeared in the testis.
      Title: Spermatogenesis-associated 48 is essential for spermatogenesis in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein SPMIP7
    Names
    post meiotic spermatogenesis 1
    post-meiotic spermatogenesis protein 1
    spermatogenesis associated 48
    spermatogenesis-associated protein 48
    uncharacterized protein C7orf72 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347068.2 → NP_001333997.1  protein SPMIP7 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL662805
      Consensus CDS
      CCDS88132.1
      UniProtKB/Swiss-Prot
      Q5NC83, Q9D5M8
      UniProtKB/TrEMBL
      F8WJ82
      Related
      ENSMUSP00000020410.6, ENSMUST00000020410.11

    2. NM_001382244.2 → NP_001369173.1  protein SPMIP7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL662805
      Conserved Domains (1) summary
      pfam15073
      Location:106 → 233
      DUF4540; Domain of unknown function (DUF4540)

    3. NM_001382245.2 → NP_001369174.1  protein SPMIP7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL662805
      Conserved Domains (1) summary
      pfam15073
      Location:102 → 229
      DUF4540; Domain of unknown function (DUF4540)

    4. NM_001401546.1 → NP_001388475.1  protein SPMIP7 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL662805

    5. NM_001401547.1 → NP_001388476.1  protein SPMIP7 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL662805

    6. NM_028669.2 → NP_082945.1  protein SPMIP7 isoform 2

      See identical proteins and their annotated locations for NP_082945.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR. lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AL662805
      Consensus CDS
      CCDS48752.1
      UniProtKB/Swiss-Prot
      Q5NC83
      Related
      ENSMUSP00000105300.2, ENSMUST00000109678.3
      Conserved Domains (1) summary
      pfam15073
      Location:18 → 145
      DUF4540; Domain of unknown function (DUF4540)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      11412089..11465658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514826.1 → XP_006514889.1  protein SPMIP7 isoform X2

      See identical proteins and their annotated locations for XP_006514889.1

      Conserved Domains (1) summary
      pfam15073
      Location:55 → 182
      DUF4540; Domain of unknown function (DUF4540)

    2. XM_017314798.2 → XP_017170287.1  protein SPMIP7 isoform X2

      Conserved Domains (1) summary
      pfam15073
      Location:55 → 182
      DUF4540; Domain of unknown function (DUF4540)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5NC83.2 GenPept UniProtKB/Swiss-Prot:Q5NC83

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