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    CTH cystathionine gamma-lyase [ Sus scrofa (pig) ]

    Gene ID: 733654, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CTHprovided by VGNC
    Official Full Name
    cystathionine gamma-lyaseprovided by VGNC
    Primary source
    VGNC:VGNC:96961
    See related
    Ensembl:ENSSSCG00000003789
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    CGL; CSE
    Expression
    Biased expression in liver (RPKM 111.3), kidney (RPKM 80.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See CTH in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (142454922..142486352, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (132027445..132050236, complement)

    Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene zinc finger RANBP2-type containing 2 Neighboring gene uncharacterized LOC106507649 Neighboring gene microRNA mir-186 Neighboring gene prostaglandin E receptor 3 Neighboring gene uncharacterized LOC110261208 Neighboring gene HIG1 domain family member 1A, mitochondrial pseudogene Neighboring gene ankyrin repeat domain 13C Neighboring gene serine and arginine rich splicing factor 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Impact of carbon monoxide/heme oxygenase on hydrogen sulfide/cystathionine-γ-lyase pathway in the pathogenesis of allergic rhinitis in guinea pigs. Yu S, et al. Otolaryngol Head Neck Surg, 2015 Mar. PMID 25583855
    2. A gene-based radiation hybrid map of the pig chromosome 6q32 region associated with a QTL for fat deposition traits. Kim JH, et al. Anim Genet, 2006 Oct. PMID 16978188
    3. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
    4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exogenous administration of CO exacerbated allergic symptoms, resulting in higher levels of both CO and heme oxygenase-1 expression, and a further reduction in H2S levels and CSE expression.
      Title: Impact of carbon monoxide/heme oxygenase on hydrogen sulfide/cystathionine-γ-lyase pathway in the pathogenesis of allergic rhinitis in guinea pigs.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cystathionine gamma-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cysteine biosynthetic process via cystathionine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transsulfuration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cystathionine gamma-lyase
    Names
    cystathionase (cystathionine gamma-lyase)
    cysteine desulfhydrase
    cysteine-protein sulfhydrase
    gamma-cystathionase
    homocysteine desulfhydrase
    NP_001038050.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044585.1 → NP_001038050.1  cystathionine gamma-lyase

      See identical proteins and their annotated locations for NP_001038050.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ499449
      UniProtKB/Swiss-Prot
      Q19QT7
      UniProtKB/TrEMBL
      A0A480SCL7, A0A4X1UCW4
      Related
      ENSSSCP00000004099.4, ENSSSCT00000004193.5
      Conserved Domains (2) summary
      PRK08776
      Location:17 → 397
      PRK08776; cystathionine gamma-synthase; Provisional
      pfam01053
      Location:19 → 395
      Cys_Met_Meta_PP; Cys/Met metabolizm PLP-dependent enzyme

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

      Range
      142454922..142486352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19QT7.1 GenPept UniProtKB/Swiss-Prot:Q19QT7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials