TAP1 transporter 1, ATP binding cassette subfamily B member [Sus scrofa (pig)] - Gene

Summary

Official Symbol: TAP1provided by VGNC
Official Full Name: transporter 1, ATP binding cassette subfamily B memberprovided by VGNC
Primary source: VGNC:VGNC:98358
See related: Ensembl:ENSSSCG00000025618
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: TAP
Expression: Ubiquitous expression in spleen (RPKM 78.6), lung (RPKM 63.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	7	NC_010449.5 (25062772..25071989, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	7	NC_010449.4 (29274670..29283290, complement)

Chromosome 7 - NC_010449.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of TAP1 candidate gene, but not its polymorphism and methylation, is associated with colonic polyp formation in a porcine model of human familial adenomatous polyposis.
Title: The expression of TAP1 candidate gene, but not its polymorphism and methylation, is associated with colonic polyp formation in a porcine model of human familial adenomatous polyposis.
data indicate that TAP1 expression is increased by demethylation of promoter CpG islands, with CpG_4, CpG_13 and CpG_15 implicated as the critical regulatory sites
Title: Age-associated methylation change of TAP1 promoter in piglet.
The TAP1 mRNA levels in GG genotype were significantly higher than that in the other two genotypes, with significant differences in the liver, lung, kidney, thymus, lymph node, duodenum and jejunum tissues.
Title: Genetic variations of TAP1 gene exon 3 affects gene expression and Escherichia coli F18 resistance in piglets.
These analyses showed that the TAP1 gene, which was related to MHC I immune regulation, had a stable and low expression level in unweaned stages; however, its expression increased in the postweaning stages.
Title: Dynamic changes in TAP1 expression levels in newborn to weaning piglets, and its association with Escherichia coli F18 resistance.
The TAP1 gene is associated with swine immune responses.
Title: Localization, expression change in PRRSV infection and association analysis of the porcine TAP1 gene.
Two splice variants of TAP1 were found.
Title: Characterization of porcine TAP genes: alternative splicing of TAP1.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ABC-type oligopeptide transporter activity	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in peptide transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: antigen peptide transporter 1

Names: putative ABC-transporter; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP); transporter associated with antigen processing 1

NP_001038046.1

EC 7.4.2.14

XP_020954029.1

EC 7.4.2.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044581.1 → NP_001038046.1 antigen peptide transporter 1

See identical proteins and their annotated locations for NP_001038046.1

Status: PROVISIONAL

Source sequence(s)

DQ227989

UniProtKB/TrEMBL

A0A8D0ZVL3, Q1ACV6

Related

ENSSSCP00000071230.2, ENSSSCT00000082786.2

Conserved Domains (3) summary

TIGR00958
Location:37 → 736

3a01208; Conjugate Transporter-2 (CT2) Family protein

pfam00664
Location:196 → 454

ABC_membrane; ABC transporter transmembrane region

cl21455
Location:488 → 716

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010449.5 Reference Sscrofa11.1 Primary Assembly

Range

25062772..25071989 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021098370.1 → XP_020954029.1 antigen peptide transporter 1 isoform X1

UniProtKB/TrEMBL

A0A8D1H710, Q1ACV5

Related

ENSSSCP00000001588.2, ENSSSCT00000001630.4

Conserved Domains (1) summary

cl26602
Location:37 → 727

SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]