U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Phykpl 5-phosphohydroxy-L-lysine phospholyase [ Mus musculus (house mouse) ]

    Gene ID: 72947, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Phykplprovided by MGI
    Official Full Name
    5-phosphohydroxy-L-lysine phospholyaseprovided by MGI
    Primary source
    MGI:MGI:1920197
    See related
    Ensembl:ENSMUSG00000020359 AllianceGenome:MGI:1920197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Agxt2l2; 2900006B13Rik
    Summary
    This gene overlaps in a tail-to-tail orientation the gene encoding heterogeneous nuclear ribonucleoprotein A/B. The terminal exon of this gene is interspersed with exons of heterogeneous nuclear ribonucleoprotein A/B. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 13.7), limb E14.5 (RPKM 13.3) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Phykpl in Genome Data Viewer
    Location:
    11 B1.3; 11 31.08 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51474751..51494091)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51584654..51603264)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Myb/SANT DNA binding domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E5223 Neighboring gene Myb/SANT DNA binding domain containing 5 like Neighboring gene CDC like kinase 4 Neighboring gene collagen, type XXIII, alpha 1 Neighboring gene STARR-positive B cell enhancer mm9_chr11:51347850-51348150 Neighboring gene STARR-positive B cell enhancer ABC_E6980 Neighboring gene STARR-seq mESC enhancer starr_29416 Neighboring gene STARR-positive B cell enhancer ABC_E3947 Neighboring gene STARR-positive B cell enhancer ABC_E255 Neighboring gene heterogeneous nuclear ribonucleoprotein A/B Neighboring gene STARR-positive B cell enhancer ABC_E8400 Neighboring gene STARR-seq mESC enhancer starr_29422 Neighboring gene STARR-positive B cell enhancer ABC_E3948 Neighboring gene required for meiotic nuclear division 5 homolog B Neighboring gene NHP2 ribonucleoprotein Neighboring gene NEDD4 binding protein 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice. Delprato A, et al. Genes Brain Behav, 2015 Nov. PMID 26449520, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    5-phosphohydroxy-L-lysine phospho-lyase
    Names
    alanine--glyoxylate aminotransferase 2-like 2
    NP_001369750.1
    NP_082674.1
    XP_006534386.1
    XP_006534387.1
    XP_006534388.1
    XP_036012913.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382821.1 → NP_001369750.1  5-phosphohydroxy-L-lysine phospho-lyase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK160557, AL645602, AL662843
      Related
      ENSMUSP00000020625.7, ENSMUST00000020625.7
      Conserved Domains (1) summary
      PRK06148
      Location:1 → 433
      PRK06148; hypothetical protein; Provisional

    2. NM_028398.3 → NP_082674.1  5-phosphohydroxy-L-lysine phospho-lyase isoform 2

      See identical proteins and their annotated locations for NP_082674.1

      Status: VALIDATED

      Source sequence(s)
      AL645602, AL662843
      Consensus CDS
      CCDS24653.1
      UniProtKB/Swiss-Prot
      Q3TUU9, Q8BG04, Q8R1K4
      Related
      ENSMUSP00000132190.2, ENSMUST00000167797.8
      Conserved Domains (2) summary
      cd00610
      Location:30 → 433
      OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...
      COG0160
      Location:15 → 435
      GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]

    RNA

    1. NR_168564.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL645602, AL662843

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      51474751..51494091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534325.5 → XP_006534388.1  5-phosphohydroxy-L-lysine phospho-lyase isoform X3

      Conserved Domains (1) summary
      PRK06148
      Location:1 → 438
      PRK06148; hypothetical protein; Provisional

    2. XM_036157020.1 → XP_036012913.1  5-phosphohydroxy-L-lysine phospho-lyase isoform X4

      Conserved Domains (1) summary
      PRK06148
      Location:14 → 240
      PRK06148; hypothetical protein; Provisional

    3. XM_006534323.5 → XP_006534386.1  5-phosphohydroxy-L-lysine phospho-lyase isoform X1

      Conserved Domains (1) summary
      PRK06148
      Location:1 → 438
      PRK06148; hypothetical protein; Provisional

    4. XM_006534324.5 → XP_006534387.1  5-phosphohydroxy-L-lysine phospho-lyase isoform X2

      Conserved Domains (1) summary
      PRK06148
      Location:1 → 433
      PRK06148; hypothetical protein; Provisional

    RNA

    1. XR_004937049.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1K4.1 GenPept UniProtKB/Swiss-Prot:Q8R1K4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous