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    Zcchc12 zinc finger, CCHC domain containing 12 [ Mus musculus (house mouse) ]

    Gene ID: 72693, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Zcchc12provided by MGI
    Official Full Name
    zinc finger, CCHC domain containing 12provided by MGI
    Primary source
    MGI:MGI:1919943
    See related
    Ensembl:ENSMUSG00000036699 AllianceGenome:MGI:1919943
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sizn1; 2810028A01Rik
    Summary
    Enables SUMO binding activity and transcription coactivator activity. Acts upstream of or within BMP signaling pathway and positive regulation of transcription by RNA polymerase II. Located in PML body and nuclear speck. Is expressed in several structures, including central nervous system; gut; paravertebral ganglion; retina; and skeletal musculature. Orthologous to several human genes including ZCCHC12 (zinc finger CCHC-type containing 12). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in CNS E18 (RPKM 76.9), whole brain E14.5 (RPKM 41.1) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zcchc12 in Genome Data Viewer
    Location:
    X A3.3; X 20.58 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (35459553..35462817)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (36195904..36199164)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 11 Neighboring gene interleukin 13 receptor, alpha 1 Neighboring gene predicted gene, 42406 Neighboring gene STARR-seq mESC enhancer starr_46996 Neighboring gene predicted gene 6023 Neighboring gene LON peptidase N-terminal domain and ring finger 3 Neighboring gene predicted gene, 25047

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Human ZCCHC12 activates AP-1 and CREB signaling as a transcriptional co-activator. Li H, et al. Acta Biochim Biophys Sin (Shanghai), 2009 Jul. PMID 19578717
    2. Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling. Cho G, et al. Mol Cell Biol, 2008 Mar. PMID 18160706, Free PMC Article
    3. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Hegarty SV, et al. Sci Rep, 2017 Aug 17. PMID 28819210, Free PMC Article
    4. XLMR candidate mouse gene, Zcchc12 (Sizn1) is a novel marker of Cajal-Retzius cells. Cho G, et al. Gene Expr Patterns, 2011 Mar-Apr. PMID 21172456, Free PMC Article
    5. Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium. Johnson JA, et al. Biol Open, 2018 Apr 16. PMID 29661797, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sizn1 is expressed by Cajal-Retzius neurons of the dorsal forebrain, beginning in their progenitor zones
      Title: XLMR candidate mouse gene, Zcchc12 (Sizn1) is a novel marker of Cajal-Retzius cells.
    2. ZCCHC12 enhanced the transcriptional activities of activator protein 1 (AP-1) and cAMP response element binding protein (CREB) as a coactivator
      Title: Human ZCCHC12 activates AP-1 and CREB signaling as a transcriptional co-activator.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger CCHC domain-containing protein 12
    Names
    smad-interacting zinc finger protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358476.1 → NP_001345405.1  zinc finger CCHC domain-containing protein 12

      Status: VALIDATED

      Source sequence(s)
      AI846160, AL512597, BY099102
      Consensus CDS
      CCDS30058.1
      UniProtKB/Swiss-Prot
      Q9CZA5
      Conserved Domains (1) summary
      pfam14893
      Location:10 → 212
      PNMA

    2. NM_001358477.1 → NP_001345406.1  zinc finger CCHC domain-containing protein 12

      Status: VALIDATED

      Source sequence(s)
      AI846160, AL512597
      Consensus CDS
      CCDS30058.1
      UniProtKB/Swiss-Prot
      Q9CZA5
      Conserved Domains (1) summary
      pfam14893
      Location:10 → 212
      PNMA

    3. NM_001358478.1 → NP_001345407.1  zinc finger CCHC domain-containing protein 12

      Status: VALIDATED

      Source sequence(s)
      AI846160, AL512597, BC055714
      Consensus CDS
      CCDS30058.1
      UniProtKB/Swiss-Prot
      Q9CZA5
      Related
      ENSMUSP00000044550.4, ENSMUST00000048067.10
      Conserved Domains (1) summary
      pfam14893
      Location:10 → 212
      PNMA

    4. NM_001358479.1 → NP_001345408.1  zinc finger CCHC domain-containing protein 12

      Status: VALIDATED

      Source sequence(s)
      AI846160, AL512597
      Consensus CDS
      CCDS30058.1
      UniProtKB/Swiss-Prot
      Q9CZA5
      Conserved Domains (1) summary
      pfam14893
      Location:10 → 212
      PNMA

    5. NM_001358480.1 → NP_001345409.1  zinc finger CCHC domain-containing protein 12

      Status: VALIDATED

      Source sequence(s)
      AI846160, AL512597
      Consensus CDS
      CCDS30058.1
      UniProtKB/Swiss-Prot
      Q9CZA5
      Conserved Domains (1) summary
      pfam14893
      Location:10 → 212
      PNMA

    6. NM_028325.4 → NP_082601.1  zinc finger CCHC domain-containing protein 12

      See identical proteins and their annotated locations for NP_082601.1

      Status: VALIDATED

      Source sequence(s)
      AI846160, AK012833, BY234361
      Consensus CDS
      CCDS30058.1
      UniProtKB/Swiss-Prot
      Q9CZA5
      Related
      ENSMUSP00000110913.3, ENSMUST00000115258.9
      Conserved Domains (1) summary
      pfam14893
      Location:10 → 212
      PNMA

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      35459553..35462817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162103.1 → XP_036017996.1  zinc finger CCHC domain-containing protein 12 isoform X1

      UniProtKB/Swiss-Prot
      Q9CZA5
      Related
      ENSMUSP00000110911.2, ENSMUST00000115256.2
      Conserved Domains (1) summary
      pfam14893
      Location:10 → 212
      PNMA

    2. XM_036162105.1 → XP_036017998.1  zinc finger CCHC domain-containing protein 12 isoform X1

      UniProtKB/Swiss-Prot
      Q9CZA5
      Conserved Domains (1) summary
      pfam14893
      Location:10 → 212
      PNMA

    3. XM_011250974.4 → XP_011249276.1  zinc finger CCHC domain-containing protein 12 isoform X1

      See identical proteins and their annotated locations for XP_011249276.1

      UniProtKB/Swiss-Prot
      Q9CZA5
      Conserved Domains (1) summary
      pfam14893
      Location:10 → 212
      PNMA

    4. XM_036162104.1 → XP_036017997.1  zinc finger CCHC domain-containing protein 12 isoform X1

      UniProtKB/Swiss-Prot
      Q9CZA5
      Conserved Domains (1) summary
      pfam14893
      Location:10 → 212
      PNMA

    5. XM_006541399.3 → XP_006541462.1  zinc finger CCHC domain-containing protein 12 isoform X1

      See identical proteins and their annotated locations for XP_006541462.1

      UniProtKB/Swiss-Prot
      Q9CZA5
      Conserved Domains (1) summary
      pfam14893
      Location:10 → 212
      PNMA

    6. XM_017318630.3 → XP_017174119.1  zinc finger CCHC domain-containing protein 12 isoform X1

      UniProtKB/Swiss-Prot
      Q9CZA5
      Conserved Domains (1) summary
      pfam14893
      Location:10 → 212
      PNMA
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZA5.1 GenPept UniProtKB/Swiss-Prot:Q9CZA5

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