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    Slc43a1 solute carrier family 43, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 72401, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Slc43a1provided by MGI
    Official Full Name
    solute carrier family 43, member 1provided by MGI
    Primary source
    MGI:MGI:1931352
    See related
    Ensembl:ENSMUSG00000027075 AllianceGenome:MGI:1931352
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lat3; PB39; Pov1; R00504; 2610016F07Rik
    Summary
    Enables L-isoleucine transmembrane transporter activity; L-leucine transmembrane transporter activity; and L-valine transmembrane transporter activity. Involved in L-leucine transport; L-valine transmembrane transport; and isoleucine transport. Acts upstream of or within L-amino acid transport. Located in plasma membrane. Is expressed in several structures, including alimentary system; blood island; liver; neural ectoderm; and nose. Orthologous to human SLC43A1 (solute carrier family 43 member 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in liver E14.5 (RPKM 49.5), liver E14 (RPKM 42.1) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc43a1 in Genome Data Viewer
    Location:
    2 D; 2 49.45 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84669196..84693930)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (84838855..84863586)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05011 Neighboring gene smoothelin-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E2628 Neighboring gene RIKEN cDNA D930003E18 gene Neighboring gene translocase of inner mitochondrial membrane 10 Neighboring gene reticulon 4 receptor-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E8789 Neighboring gene STARR-positive B cell enhancer ABC_E11144 Neighboring gene STARR-positive B cell enhancer ABC_E2629 Neighboring gene solute carrier family 43, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protein characterization of NA+-independent system L amino acid transporter 3 in mice: a potential role in supply of branched-chain amino acids under nutrient starvation. Fukuhara D, et al. Am J Pathol, 2007 Mar. PMID 17322374, Free PMC Article
    2. cDNA sequencing and analysis of POV1 (PB39): a novel gene up-regulated in prostate cancer. Cole KA, et al. Genomics, 1998 Jul 15. PMID 9722952
    3. Identification of LAT4, a novel amino acid transporter with system L activity. Bodoy S, et al. J Biol Chem, 2005 Mar 25. PMID 15659399
    4. The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Chung J, et al. Sci Signal, 2015 Apr 14. PMID 25872869, Free PMC Article
    5. Mutations in linker-2 of KLF1 impair expression of membrane transporters and cytoskeletal proteins causing hemolysis. Huang S, et al. Nat Commun, 2024 Aug 15. PMID 39147774, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-isoleucine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-isoleucine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-leucine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-leucine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-valine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-valine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neutral L-amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-leucine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-leucine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-valine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-valine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in isoleucine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in isoleucine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of L-leucine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutral amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neutral amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neutral amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutral amino acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in podocyte foot ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large neutral amino acids transporter small subunit 3
    Names
    L-type amino acid transporter 3
    prostate cancer overexpressed gene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081349.2 → NP_001074818.2  large neutral amino acids transporter small subunit 3 isoform 1

      See identical proteins and their annotated locations for NP_001074818.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK046758, BX522717, CJ307166
      Consensus CDS
      CCDS50624.1
      UniProtKB/TrEMBL
      G3X8X3
      Related
      ENSMUSP00000028469.8, ENSMUST00000028469.14
      Conserved Domains (1) summary
      cd06174
      Location:118 → 262
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    2. NM_001083809.1 → NP_001077278.1  large neutral amino acids transporter small subunit 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a distinct ATG and an isoform (3) with a shorter, distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK031215
      Consensus CDS
      CCDS38162.1
      UniProtKB/TrEMBL
      A2ATS4
      Related
      ENSMUSP00000107252.2, ENSMUST00000111625.2
      Conserved Domains (1) summary
      cd06174
      Location:101 → 245
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    3. NM_024497.1 → NP_078773.1  large neutral amino acids transporter small subunit 3 isoform 2

      See identical proteins and their annotated locations for NP_078773.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      BC053747, CJ186653, CJ307166
      Consensus CDS
      CCDS38163.1
      UniProtKB/Swiss-Prot
      A2ATS3, Q8BSM7, Q9D0H7
      Related
      ENSMUSP00000107251.2, ENSMUST00000111624.8
      Conserved Domains (1) summary
      cl28910
      Location:75 → 241
      MFS; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      84669196..84693930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500231.5 → XP_006500294.1  large neutral amino acids transporter small subunit 3 isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:51 → 217
      MFS; Major Facilitator Superfamily

    2. XM_036162592.1 → XP_036018485.1  large neutral amino acids transporter small subunit 3 isoform X2

      Conserved Domains (1) summary
      cd06174
      Location:202 → 368
      MFS; Major Facilitator Superfamily

    3. XM_036162593.1 → XP_036018486.1  large neutral amino acids transporter small subunit 3 isoform X4

    4. XM_036162591.1 → XP_036018484.1  large neutral amino acids transporter small subunit 3 isoform X1

      Conserved Domains (1) summary
      cl28910
      Location:202 → 368
      MFS; Major Facilitator Superfamily

    5. XM_036162594.1 → XP_036018487.1  large neutral amino acids transporter small subunit 3 isoform X5

    6. XM_036162595.1 → XP_036018488.1  large neutral amino acids transporter small subunit 3 isoform X7

      Conserved Domains (1) summary
      cl28910
      Location:197 → 307
      MFS; Major Facilitator Superfamily

    7. XM_006500230.4 → XP_006500293.1  large neutral amino acids transporter small subunit 3 isoform X6

      See identical proteins and their annotated locations for XP_006500293.1

      UniProtKB/Swiss-Prot
      A2ATS3, Q8BSM7, Q9D0H7
      Related
      ENSMUSP00000112642.2, ENSMUST00000121114.8
      Conserved Domains (1) summary
      cl28910
      Location:75 → 241
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BSM7.1 GenPept UniProtKB/Swiss-Prot:Q8BSM7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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